Abstract: 93 cases with schizophrenia, its major clinical indication being negative symptom were treated by Clozapine, Sulpirideand their combination. The curative effect and the SANS content table of the pretreatment and posttreatment were analysed. The results showed that the curative effects of the three were similar. The SANS contents table after the treatment in Clozapine group and Sulpiride group had no evident difference and that in the combination was lower than in Clozapine group and Sulpiride group, especially the two symptoms of apathia and lack of thought had markedly improved.