Abstract: To evaluate significance of serum levels of albumin (Alb), prealbumin (PA), transferrin (TF ) in patients with Feishen Liangru Syndrome (FSLXS ) of chronic obktructlve pulmonary dlseasr (COPD) in TCM syndrome fifferentiation, eight patients with SOPD were observed. The results showed that FSLXS was the major syndrome of convalescent stage which was accunted for 8l. 8%. Tanre Yufei Sgndrome (FRYFS) Tanshi Yunfei Syndrome (TSYFS) were mainly observed at acute stage shich was ac counted for 66. 7% and 55. 6% respectively. This study chose serum Albumin (Alb). Preulbumin (PA) and Transferrin (TF) as the monitoring parameters. We found that te serum levels of PA, TF in patients with FSLXS were lower than those in normal controls, the change in TF level was more obvious (P 0.01), the decrease of serum Alb was not obvious (P 0. 05) The results could be considered as a part of the comprehensive experimenial paramelers for TCM syndrome differentiation in FSLXS of xhronic ostructive pulmonary ciease