P_(16)蛋白在食管鳞状细胞癌的表达及临床意义

EXPRESSION OF P_(16) PROTEIN IN SQUAMOUS CELL CARCINOMA OF ESOPHAGUS AND ITS CLINICAL SIGNIFICANCE

摘要: 应用免疫络化S－P法检测88例食管浸润世鳞癌P16蛋白的表达，结果P16蛋白阳性率为55．68％（49/88），其阳性颗粒位于细胞浆内；组织学Ⅰ、Ⅱ、Ⅲ级阳性率分予的85．71％（18/21）、55.13％（16/29）、39.47％（15/38）（P＜0．01）；淋巴结转移组和无转移组阳世事分别为36.36％（12／33），67．27％（37／55）（P＜0．01）;3年生存率P16蛋白阳性组和阴性组分别36％和16．67％。结果表明食管鳞癌中P16蛋白的表达可以反映肿瘤的分化程度和转移情况．提示P16蛋白的检测可作为食管鳞癌的重要预后指标之一。

Abstract: to study the expression of p16 protein in esphageal squamous cell carcima (escc) and itsclinicoodringical swificance, the ewion of p16 protein was analyzed by forstochedcal staining (s -p) using for - melin fixed, paraffin ededded sectbo of 88 cases with invasive squamous cell carioma of esoph-agus. expression of p16 protein was detected in 55. 68 % (49/88) of esccs. the opnaion wi correla ed withthe un histologc grade (grade 185. 71% (18/21), ii 55. 13% (16/29), iii39. 47% (15/38) (p 0.01) and lymph nede metastased) positive 36. 3% (12/33), negtive 67. 27% (37/55) (p 0.01). theresults suggst that the expression of p16 protein in rm an favorable prognosis of the lesion.