纯化人白细胞α型干扰素治疗肾综合征出血热临床探讨

EXPERIMENT OF TREATMENT OF HEMORRHAGE FEVER OF RENAL SYNDROME WITH PURIFIED IFN-α

摘要: 作者使用纯化人白细胞。型干扰素（IFN—α）治疗肾综合征出血热（HFRS）30例，并与对照组（生理盐水加0．5％白蛋白冻干）30例进行比较，结果发现治疗组尿蛋白消失时间、血小板恢复正常时间、BUN和Cr复常时间均明显短于对照组（P＜0．05），渡过低血压期及少尿期病例的百分率明显高于对照组（P＜0．05），而在病程、并发症发生率、死亡率等方面差异不明显。结果提示对HFRS患者早期使用干扰素具有促进肾功能恢复、减轻肾损害、加快尿蛋白消失和血小板回升等作用。

Abstract: Thirty cases of hemorrhnge fever of renal syndrome (HFRS) treated with purified human IFN - a from Dec., 1991 to Dec., 1992 were compared with the control group. The result demonstrated that urine proteins platelet, BUN, Cr returned to normal rapider than the control group significantly (P 0. 05). The percentage of getting over hypotension and oliguria phase was significantlyhigher than the control group (P 0. 05). Therefore we think that IFN - α may promote the renal function recovery of HFRS, rising platelet, preventing ill standia, increasing advert phase rates.