Abstract: Aim: to evaluate the clinical efficacy and safety of Sparfloxacin tablets, a random con-trast study compared with Lomefloxacin tablts in 73 patients with acute infections caused by bacteria wasperformed. Result: the recovered rate (84. 21 % ) and effective rate (92. 11 % ) in the test group werehigher than the recovered rate (65. 71 % ) and effective rate (82. 86% ) in the contrast group, thoughthere were no significant differance statistically (P O. O5). The side - effetive rate was 5. 3% in thetest group, which was lower than that (14. 3% ) in control group (P 0. 05 ). Conclusion:Sparfloxacin tablets are better than Lomefloxacin tablets in treating acute infectious-diseases caused by bac-teria.