细胞周期蛋白E在胃癌中的表达及其与细胞增殖活性的关系

EXPRESSION OF CYCLIN E IN GASTRIC CARCINOMAS AND ITS RELATIONSHIP WITH CELL PROLIFERATIVE ACTIVITY

摘要: 目的 :研究细胞周期蛋白E有胃癌组织中的表达与细胞增殖活性及其它临床病理因素的关系。方法 :用免疫组织化学方法检测 40例胃癌组织中细胞周期蛋白E和Ki-6 7的表达。结果 :胃癌组织中细胞周期蛋白E和Ki-6 7表达阳性率分别为 45 %和 72 5 % ,在细胞周期蛋白E阳性胃癌中Ki-6 7阳性率明显高于细胞周期蛋白E阴性胃癌 (P 0 0 5 )。此外还发现细胞周期蛋白E在胃癌中的表达与肿瘤浸润深度、淋巴结转移和TNM分期密切相关 ( P 0 0 5 )。结论 :提示细胞周期蛋白E在胃癌中的表达与Ki-6 7的表达有关 ,并在肿瘤的进展中起一定作用

Abstract: Objective: Studying the Expression of cyclin E in gastric carcinomas and its relationship with cell proliferative activity and other pathological elements in clinic.Motheds:Expression of cyclin E and Ki-67 in 40 cases of gastric carcinomas was detected by immunohistochemical method.Results:The total positive expression rate of cyclin E and Ki-67 was 45% and 72.5%,respectively.The incidence of Ki-67 expression was higer in cyclin E positive tumors than in the other tumors.Inddition,cyclin E expression was observed frequetly in deeply invasive tumors with lymph node metastasis,and tumors with advanced stage.Conclusion:The expression of cyclin E correlates with Ki-67 expression and might contribute to the progression of gastric carcinoma.