Abstract: To estimate the therapy effect of inhaling ipratropium bromide (Atrovnt) withmetered inhaler, jet - nebulinzer, and hand - hold nebulizer respectively. Methods: Pratropium bromidewas in haled by the randomed, self - controled, single - blinded trail in 25 inpatients with chronic obstructive pulmonary disease (COPD) who were divided into two groups - COPD in acute phase and COPD instable phase. Four - hour lung function was recorded after inhaling ipratropium bromide. Result: Afterinhaling ipratropium bromide, no significant change was found in VC, V50, V25, On the increase ofFVC%, FEV1%, Vmax% of COPD in acute phase, hand - hold nebulizer was significantly higher thanjet - nebulizer, metered does inhaler was the lowest, those in stable phase, metered dose inhaler was similar to jet - nebulizer and hand - hold nebulizer was significantly higher. Conclusion: Metered dose inhaleris only good for COPD in stable phase, hand - hold nebulizer and jet - nebulizer are both good for COPD inacute or stable phase and hand - hold nebulizer is better.