非小细胞肺癌患者手术前后血清SIL-2R的临床研究
CHANGES OF PREOPERATIVE AND POSTOPERATIVE SOLUBLE INTERLEUKIN-2 RECEPTOR(SIL-2) SERUM LEVELS IN NON-SMALL CELL LUNG CARCINOMA
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摘要: 目的 :探讨血清可溶性白细胞介素 2受体 (SIL -2 )的表达水平与非小细胞肺癌患者 (NSCLC)病期和预后的关系。方法 :对 50例非小细胞肺癌患者 (NSCLC)手术前 ,术后 10d和术后 30d血清SIL -2R水平进行了动态研究。采用酶标双抗体夹心法测SIL -2R水平。结果 :NSCLC患者SIL -2R表达水平明显高于正常人 ,P 0 0 0 1。未复发组的患者术后SIL -2R表达水平呈现一个暂时性增高到逐渐下降近正常 ,表明其术后免疫功能从暂时抑制到逐渐恢复的过程。复发组的患者术后SIL -2R表达水平持续居高不下 ,表明其术后免疫功能持续低下。结论 :未复发组与复发组比较P 0 0 0 1,提示SIL -2R表达水平与NSCLC患者的病期和预后有密切关系Abstract: Objective:To study the relationship between the soluble Intenleukin-2 receptor(sIL-2)serum levels and the process and prognosis of the patients with non-small cell Lung carcinoma(NSCLC).Methods:The sIL-2 serum levels of 50 patients in NSCLC were measured with enzyme immunoassay before surgery and 10 and 30 days after surgery.Result:The sIL-2R serum levels of patients with NSCLC more were significantly enhanced than those of controls( P 0 001). There was a period of immune suppression after surgery. The sIL-2R serum levels of patients with recurrence were significantly enhanced than those of patients without recurrence( P 0 001). The period of immunsuppression in patients with recurrence was longer than that of without recurrence. Conclusions:The changes of sIL-2R serum levels are closely related to the prognosis of patients with NSCLC.
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