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季明春, 龚卫娟, 管洪文, 刘歆农, 刘庆宏. 结肠直肠癌患者PBL、LNL、TIL免疫功能的比较研究[J]. 实用临床医药杂志, 2001, (4): 275-279. DOI: 10.3969/j.issn.1672-2353.2001.04.001
引用本文: 季明春, 龚卫娟, 管洪文, 刘歆农, 刘庆宏. 结肠直肠癌患者PBL、LNL、TIL免疫功能的比较研究[J]. 实用临床医药杂志, 2001, (4): 275-279. DOI: 10.3969/j.issn.1672-2353.2001.04.001
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FUNCTIONAL CHARACTERIZATION OF TUMOR-INFILTRATING LYMPHOCYTES LYMPH NODE LYMPHOCYTES AND PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH COLORECTAL CARCINOMA[J]. Journal of Clinical Medicine in Practice, 2001, (4): 275-279. DOI: 10.3969/j.issn.1672-2353.2001.04.001
Citation: FUNCTIONAL CHARACTERIZATION OF TUMOR-INFILTRATING LYMPHOCYTES LYMPH NODE LYMPHOCYTES AND PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH COLORECTAL CARCINOMA[J]. Journal of Clinical Medicine in Practice, 2001, (4): 275-279. DOI: 10.3969/j.issn.1672-2353.2001.04.001
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结肠直肠癌患者PBL、LNL、TIL免疫功能的比较研究

FUNCTIONAL CHARACTERIZATION OF TUMOR-INFILTRATING LYMPHOCYTES LYMPH NODE LYMPHOCYTES AND PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH COLORECTAL CARCINOMA

    摘要
  • 摘要: 目的:研究结肠直肠癌患者外周血淋巴细胞、肿瘤浸润淋巴细胞、肿瘤引流淋巴结淋巴细胞的免疫学功能,为研究结肠直肠癌患者的过继性细胞免疫治疗积累实验资料.方法:比较结肠直肠癌患者不同来源淋巴细胞的细胞表型、NK活性、LAK活性、特异性细胞毒活性、体外增殖反应等特征.结果:结肠直肠癌患者PBL、LNL、TIL在免疫功能上有较大差别.从结肠直肠癌患者肿瘤原位新鲜分离的LNL和TIL的NK活性、LAK活性和特异性细胞毒活性均明显低于PBL.PBL中含有较多的NK细胞,LNL中含有较多的B细胞和CD4+细胞,PBL和无肿瘤转移的LNL的细胞增殖能力明显高于TIL和有肿瘤转移的LNL.结论:一般情况较好的结肠直肠癌患者外周血淋巴细胞的免疫学指标和正常人PBL相比基本正常.

     

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