沙维伟, 张晓斌, 耿德勤, 程言博. 5-羟色胺2A受体基因多态性与精神疾病患者自杀未遂的关联性研究[J]. 实用临床医药杂志, 2005, (1): 5-8. DOI: 10.3969/j.issn.1672-2353.2005.01.003
引用本文: 沙维伟, 张晓斌, 耿德勤, 程言博. 5-羟色胺2A受体基因多态性与精神疾病患者自杀未遂的关联性研究[J]. 实用临床医药杂志, 2005, (1): 5-8. DOI: 10.3969/j.issn.1672-2353.2005.01.003
SHA Wei-wei, ZHANG Xiao-bin, GENG De-qin, CHENG Yan-bo. ASSOCIATION OF POLYMORPHISM OF SEROTONIN 2A RECEPTOR GENE WITH ATTEMPTED SUICIDE IN PSYCHIATRIC PATIENTS[J]. Journal of Clinical Medicine in Practice, 2005, (1): 5-8. DOI: 10.3969/j.issn.1672-2353.2005.01.003
Citation: SHA Wei-wei, ZHANG Xiao-bin, GENG De-qin, CHENG Yan-bo. ASSOCIATION OF POLYMORPHISM OF SEROTONIN 2A RECEPTOR GENE WITH ATTEMPTED SUICIDE IN PSYCHIATRIC PATIENTS[J]. Journal of Clinical Medicine in Practice, 2005, (1): 5-8. DOI: 10.3969/j.issn.1672-2353.2005.01.003

5-羟色胺2A受体基因多态性与精神疾病患者自杀未遂的关联性研究

ASSOCIATION OF POLYMORPHISM OF SEROTONIN 2A RECEPTOR GENE WITH ATTEMPTED SUICIDE IN PSYCHIATRIC PATIENTS

  • 摘要: 目的探讨5-羟色胺2A(5-HT2A)受体基因A-1 438G、 T102C多态性与精神疾病患者的自杀未遂之间的关系.方法对52例有自杀未遂的精神疾病患者和64例无自杀的精神疾病患者及63例正常人,按常规方法提取DNA, 用限制性片段长度多态性方法分析5-HT2A受体基因的多态性.结果 5-HT2A受体基因A-1 438G和T102C两位点多态性呈完全连锁不平衡;自杀未遂组的A-1 438G、 T102C多态性位点的T/G等位基因频率高于正常对照组(P<0.05), 自杀未遂组与正常对照组间的基因型分布的差异也有显著性(P<0.05).结论精神疾病患者的自杀未遂与5-HT2A受体基因的A-1 438G、 T102C多态性有关, T/G等位基因可能是自杀行为的危险因素.

     

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