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马忠平, 顾光华, 贾玉芳. 蛋白酶体抑制剂MG132对Caov-3细胞中NF-κB、CycLinD1表达的影响[J]. 实用临床医药杂志, 2011, (17): 46-48. DOI: 10.3969/j.issn.1672-2353.2011.17.015
引用本文: 马忠平, 顾光华, 贾玉芳. 蛋白酶体抑制剂MG132对Caov-3细胞中NF-κB、CycLinD1表达的影响[J]. 实用临床医药杂志, 2011, (17): 46-48. DOI: 10.3969/j.issn.1672-2353.2011.17.015
shu
MA Zhong-ping, GU Guang-hua, JIA Yu-fang. The expression of NF-κB、CyclinD1 in Caov-3 cells after using proteasome inhibitor MG132[J]. Journal of Clinical Medicine in Practice, 2011, (17): 46-48. DOI: 10.3969/j.issn.1672-2353.2011.17.015
Citation: MA Zhong-ping, GU Guang-hua, JIA Yu-fang. The expression of NF-κB、CyclinD1 in Caov-3 cells after using proteasome inhibitor MG132[J]. Journal of Clinical Medicine in Practice, 2011, (17): 46-48. DOI: 10.3969/j.issn.1672-2353.2011.17.015
shu

蛋白酶体抑制剂MG132对Caov-3细胞中NF-κB、CycLinD1表达的影响

The expression of NF-κB、CyclinD1 in Caov-3 cells after using proteasome inhibitor MG132

    摘要
  • 摘要: 目的 研究蛋白酶体抑制剂MG132用药前后卵巢癌细胞株Caov-3细胞内NF-κB、CycLinD1表达情况.方法 通过细胞培养和免疫组化SP法测定用药前后Caov-3细胞中NF-κB、CycLinD1的表达情况.结果 免疫组化结果显示MG132作用24h后Caov-3细胞中NF-κB、CycLinD1表达均下调,与对照组比较差异有显著性(P＜0.01),药物作用组各组间两两比较差异有显著性(P＜0.01).结论 MG132能诱导卵巢癌细胞Caov-3凋亡、抑制其增长,其机制可能与NF-κB、CycLinD1表达抑制有关.

     

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