非小细胞肺癌埃克替尼靶向治疗期间进行手术干预的临床观察

Clinical observation of surgical intervention on patients with non-small cell lung cancer after icotinib hydrochloride targeted therapy

摘要: 目的：探讨盐酸埃克替尼靶向治疗期间进行手术干预治疗非小细胞肺癌（NSCLC）的可行性。方法回顾性分析经盐酸埃克替尼靶向治疗后在不同时机采取手术干预的6例 NSCLC 患者的临床资料。结果6例患者经盐酸埃克替尼靶向治疗后，均施行手术干预治疗，其中行左全肺切除1例，肺叶切除3例，局部切除2例。手术过程顺利，术后给予化疗2例，继续靶向治疗3例，观察1例。结论盐酸埃克替尼靶向治疗期间给予适当、适时、主动的手术干预是可行的。

Abstract: Objective To investigate the feasibility of surgical intervention on treatment of patients with non-small cell lung cancer (NSCLC)in icotinib hydrochloride targeted treatment. Methods Clinical materials of 6 patients given surgical intervention after icotinib hydrochloride tar-geted therapy were retrospectively analyzed.Results Among 6 patients,1 patient had left total pneumonectomy,3 patients had pulmonary lobectomy,2 patients had local excision.After opera-tion,number of patients with chemotherapy,targeted therapy and observation only was 2,3 and 1 case respectively.Conclusion Well-designed and active surgical intervention may be feasible for patient during icotinib hydrochloride targeted therapy.