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金世禄, 屈冬冬. 非酒精性脂肪肝患者血清TNF-α、IL-6水平变化及其与胰岛素抵抗的相关性[J]. 实用临床医药杂志, 2015, (5): 48-50. DOI: 10.7619/jcmp.201505015
引用本文: 金世禄, 屈冬冬. 非酒精性脂肪肝患者血清TNF-α、IL-6水平变化及其与胰岛素抵抗的相关性[J]. 实用临床医药杂志, 2015, (5): 48-50. DOI: 10.7619/jcmp.201505015
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JIN Shilu, QU Dongdong. Changes of serum tumor necrosis factor-α and interlukin-6 levels in patients with non-alcoholic fatty liver and its correlation with insulin resistance[J]. Journal of Clinical Medicine in Practice, 2015, (5): 48-50. DOI: 10.7619/jcmp.201505015
Citation: JIN Shilu, QU Dongdong. Changes of serum tumor necrosis factor-α and interlukin-6 levels in patients with non-alcoholic fatty liver and its correlation with insulin resistance[J]. Journal of Clinical Medicine in Practice, 2015, (5): 48-50. DOI: 10.7619/jcmp.201505015
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非酒精性脂肪肝患者血清TNF-α、IL-6水平变化及其与胰岛素抵抗的相关性

Changes of serum tumor necrosis factor-α and interlukin-6 levels in patients with non-alcoholic fatty liver and its correlation with insulin resistance

    摘要
  • 摘要: 目的 探讨非酒精性脂肪肝(NAFL)患者血清肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)的水平变化及其与胰岛素抵抗的相关性.方法 选取39例NAFL患者为NAFL组,另选取同期健康体检者30例为对照组.比较2组空腹血糖(FBG)、胰岛索抵抗指数(HOMA-IR)、IL-6及TNF-α水平变化,分析HOMA-IR与血清IL-6和TNF-α水平的关系.结果 NAFL组的FBG、HOMA-IR、IL-6及TNF-α水平高于对照组,差异有统计学意义(P＜0.05,P＜0.01).Pearson相关性分析结果显示,HOMA-IR与IL-6、TNF-α具有显著正相关(r=0.649,0.724,P＜0.01).结论 NAFL患者血清IL-6和TNF-α水平显著升高,且与胰岛素抵抗关系密切.

     

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