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许峥嵘, 刘明, 孙海峰, 胡利梅, 左丽娟, 张秋子. Graves病合并糖代谢异常者一级亲属胰岛素抵抗的影响因素及预防[J]. 实用临床医药杂志, 2015, (15): 41-43. DOI: 10.7619/jcmp.201515012
引用本文: 许峥嵘, 刘明, 孙海峰, 胡利梅, 左丽娟, 张秋子. Graves病合并糖代谢异常者一级亲属胰岛素抵抗的影响因素及预防[J]. 实用临床医药杂志, 2015, (15): 41-43. DOI: 10.7619/jcmp.201515012
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XU Zhengrong, LIU Ming, SUN Haifeng, HU Limei, ZUO Lijuan, ZHANG Qiuzi. Influencing factors and prevention of insulin resistance in first-degree relatives of Graves disease patients with abnormal glucose metabolism[J]. Journal of Clinical Medicine in Practice, 2015, (15): 41-43. DOI: 10.7619/jcmp.201515012
Citation: XU Zhengrong, LIU Ming, SUN Haifeng, HU Limei, ZUO Lijuan, ZHANG Qiuzi. Influencing factors and prevention of insulin resistance in first-degree relatives of Graves disease patients with abnormal glucose metabolism[J]. Journal of Clinical Medicine in Practice, 2015, (15): 41-43. DOI: 10.7619/jcmp.201515012
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Graves病合并糖代谢异常者一级亲属胰岛素抵抗的影响因素及预防

Influencing factors and prevention of insulin resistance in first-degree relatives of Graves disease patients with abnormal glucose metabolism

    摘要
  • 摘要: 目的 观察Graves病合并糖代谢异常患者一级亲属的甲状腺功能变化,并分析多个参数与胰岛素抵抗的相关性.方法 选择张家口地区有Graves病合并糖代谢异常患者的家属进行调查.对先证者的父母、同胞、子代进行甲状腺功能测定,确定一级亲属组.对研究对象测量身高、体质量和血压,计算体质量指数,测定空腹血糖、胰岛素、甲状腺功能.采用稳态模型评估法评估HOMA-IR.结果 治疗前,观察组甲状腺激素水平明显高于对照组(P＜0 05).观察组患者空腹红细胞胰岛素受体数目及亲和常数的比较都明显低于对照组.2组患者空腹的血糖和胰岛素无显著差异(P＞0.05),但在餐后2h,观察组的胰岛素又明显高于对照组(P＜0.05).结论 GD合并糖代谢异常患者一级亲属组血糖异常发生率较正常对照组高.

     

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