Abstract: Objective To compare the effect of closed wet dressing and vaseline gauze applied in donor site.Methods A total of 60 patients with donor site wound (lateral thigh) underwent surgery were divided into wet dressing group (30 cases) and vaseline gauze group (30 cases),and the pain degree of donor area,exudation,healing time and incision scar were compared.Results Pain degree at 4,7 and 10 days after operation in wet dressing group was lighter than that of vaseline gauze group,the difference was statistically significant (P ＜ 0.05);but pain at 15 d showed no statistically significant difference (P ＞ 0.05).Exudate in wet dressing group was obviously less,wound healing time was shorter,and scar as well as pigmentation ratio was lower than that in vaseline gauze group,and the differences were statistically significant (P ＜ 0.05).Conclusion Application of closed wet dressing in the donor site can relieve the pain of patients with early postoperative pain,reduce the leakage of the wound,shorten the healing time,and has less pigmentation and scar hyperplasia.