益生菌对反复呼吸道感染儿童免疫功能和临床疗效的影响

屈晖; 贺金娥; 李佳; 李亚梅; 王宽峰

doi:10.7619/jcmp.201907021

益生菌对反复呼吸道感染儿童免疫功能和临床疗效的影响

Effect of probiotics on the immune function and clinical efficacy in children with recurrent respiratory tract infection

摘要

摘要:
目的探讨益生菌对反复呼吸道感染(RRTI)儿童免疫功能和临床疗效的影响。
方法连续性纳入RRTI患儿92例，将其随机分为研究组和对照组，各46例。2组均给予匹多莫德口服，研究组在此基础上增加双歧杆菌三联活菌散口服，所有患儿治疗3个月，随访时间超过1年。比较2组患儿治疗前后血清C反应蛋白(CRP)、降钙素原(PCT)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)以及T细胞亚群的变化，并比较2组患儿的临床疗效。
结果治疗后, 2组患儿血清CRP、PCT浓度均较治疗前显著下降，血清IgG及IgA水平均较治疗前显著升高，外周血CD4⁺ T细胞计数均较前显著升高, CD8⁺ T细胞计数均较前显著下降, 差异有统计学意义(P < 0.05), 且治疗后研究组血清CRP及PCT浓度显著低于对照组，血清IgG及IgA水平显著高于对照组，外周血CD4⁺ T细胞计数显著高于对照组, CD8⁺ T细胞计数显著低于对照组, 差异均有统计学意义(P < 0.05)。但2组间临床疗效比较，差异无统计学意义(P>0.05)。
结论益生菌可有效增强RRTI患儿的免疫功能，减轻机体炎症反应。

Abstract:
Objective To investigate the effect of probiotics on the immune function and clinical efficacy in children with recurrent respiratory tract infection (RRTI).
Methods A total of 92 RRTI children were continuously enrolled and were randomly divided into study group and control group, with 46 cases in each group. Both groups were given oral treatment of pidotimod, and the study group added Bifid Triple Viable Bifidobacterium Power, all the children were treated for 3 months, and followed-up time lasted for more than 1 year. The changes of serum C-reactive protein (CRP), procalcitonin(PCT), immunoglobulin G(IgG), pmmunoglobulin A(IgA) and T cell subgroups were compared between the two groups, and the clinical efficacy between the two groups were compared.
Results After treatment, serum CRP and PCT concentrations significantly decreased, serum IgG and IgA level significantly increased, the peripheral blood T cell count of CD4⁺ was significantly increased, CD8⁺ was significantly decreased in both groups when compared with that treatment before(P < 0.05). At the same time, the study group showed lower serum CRP and PCT concentration, higher serum IgG and IgA levels, higher peripheral blood CD4⁺ T cell count, and lower CD8⁺ T cell count after treatment, when compare to the control group(P < 0.05). However, there was no statistically difference between two groups in clinical efficiency (P>0.05).
Conclusion Probiotics can effectively improve the immune function and reduce the inflammation level in RRTI children.

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