Objective  To explore the relationship between serum B-type natriuretic peptide (BNP), D-dimer (D-D), C reactive protein (CRP) and short-term prognosis in patients with massive cerebral infarction (MCI) in subacute phase.

  Methods  Totally 137 MCI patients were selected and conducted detections of serum BNP, D-D and CRP in acute phase on the basis of routine treatment and nursing, and Results were compared with healthy controls. According to the condition of prognosis at 3 months of follow-up, the MCI patients were divided into good prognosis group and poor prognosis group, and the levels of serum BNP, D-D and CRP were compared between the two groups. Multivariate Logistic regression analysis and ROC curve were used to judge the effects and predictive value of each indicator on the short-term prognosis of MCI patients.

  Results  The levels of BNP, D-D and CRP in MCI patients were significantly higher than those in healthy controls (P < 0.05). Among the 137 MCI patients, there were 46 patients with poor prognosis, and the levels of BNP, D-D and CRP in good prognosis group were significantly lower than those in poor prognosis group (P < 0.05). Logistic regression analysis showed that BNP, D-D and CRP were important influencing factors for short-term prognosis of patients with MCI (P < 0.05). ROC curve analysis showed that the Area under the curve (AUC) values of BNP, D-D and CRP in predicting short-term prognosis of MCI were 0.912, 0.806 and 0.863 respectively, and the sensitivities were 0.848, 0.870 and 0.913, respectively, and the specificities were 0.912, 0.703 and 0.670, respectively.

  Conclusion  BNP, D-D and CRP are important influencing factors for prognosis of patients with MCI in subacute phase. These indexes can be used to monitor the progression of disease, and they show a high clinical value in the judgment of short-term prognosis.