高级检索
陈士军, 张晓艳, 罗田, 王凯. 环磷酰胺联合泼尼松治疗对狼疮性肾炎患者免疫功能及血清类风湿因子、C反应蛋白及白介素-17水平的影响[J]. 实用临床医药杂志, 2019, 23(15): 75-78,82. DOI: 10.7619/jcmp.201915020
引用本文: 陈士军, 张晓艳, 罗田, 王凯. 环磷酰胺联合泼尼松治疗对狼疮性肾炎患者免疫功能及血清类风湿因子、C反应蛋白及白介素-17水平的影响[J]. 实用临床医药杂志, 2019, 23(15): 75-78,82. DOI: 10.7619/jcmp.201915020
shu
CHEN Shijun, ZHANG Xiaoyan, LUO Tian, WANG Kai. Effects of cyclophosphamide combined with prednisone on immune function, serum rheumatoid factors, C reaction protein and interleukin-17 in patients with lupus nephritis[J]. Journal of Clinical Medicine in Practice, 2019, 23(15): 75-78,82. DOI: 10.7619/jcmp.201915020
Citation: CHEN Shijun, ZHANG Xiaoyan, LUO Tian, WANG Kai. Effects of cyclophosphamide combined with prednisone on immune function, serum rheumatoid factors, C reaction protein and interleukin-17 in patients with lupus nephritis[J]. Journal of Clinical Medicine in Practice, 2019, 23(15): 75-78,82. DOI: 10.7619/jcmp.201915020
shu

环磷酰胺联合泼尼松治疗对狼疮性肾炎患者免疫功能及血清类风湿因子、C反应蛋白及白介素-17水平的影响

Effects of cyclophosphamide combined with prednisone on immune function, serum rheumatoid factors, C reaction protein and interleukin-17 in patients with lupus nephritis

    摘要
  • 摘要:
      目的  探讨环磷酰胺联合泼尼松对狼疮性肾炎(LN)患者免疫功能及血清类风湿因子(RHF)、C反应蛋白(CRP)及白介素-17(IL-17)水平的影响。
      方法  将90例LN患者随机分为对照组与观察组，每组45例。对照组单用泼尼松治疗，观察组在对照组基础上加用环磷酰胺治疗。比较2组治疗效果，比较2组治疗前后免疫功能免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体C3、补体C4、肾功能红细胞沉降率(ESR)、血清肌酐(Scr)、24 h尿蛋白定量及炎症因子(RHF、CRP及IL-17)的变化，比较2组不良反应发生率。
      结果  观察组治疗总有效率显著高于对照组(P < 0.05)。疗程结束后, 2组IgA、IgM、IgG、ESR、Scr、24 h尿蛋白定量、RHF、CRP、IL-17显著降低, C3、C4显著上升(P < 0.05), 观察组疗程结束时IgA、IgM、IgG、ESR、Scr、24 h尿蛋白定量、RHF、CRP、IL-17显著低于对照组, C3、C4显著高于对照组(P < 0.05)。2组不良反应发生率比较，差异无统计学意义(P>0.05)。
      结论  环磷酰胺联合泼尼松治疗LN疗效肯定，可改善患者免疫功能及肾功能，下调RHF、CRP、IL-17水平，且安全性较高。

     

    Abstract:
      Objective  To investigate the effects of cyclophosphamide combined with prednisone on immune function, serum rheumatoid factor (RHF), C reactive protein (CRP) and interleukin-17 (IL-17) in patients with lupus nephritis (LN).
      Methods  Totally 90 patients with LN were randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with prednisone, and the observation group was treated with cyclophosphamide on the basis of control group. The efficiency was compared between the two groups. The changes of immune function immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), complement C3, complement C4, renal function erythrocyte sedimentation rate (ESR), serum creatinine (Scr), 24-hour urinary protein quantificationand inflammatory factors (RHF, CRP and IL-17) before and after treatment were compared between the two groups. The incidence rate of adverse reactions was compared between the two groups.
      Results  The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, levels of IgA, IgM, IgG, ESR, Scr, 24-hour urinary protein quantification, RHF, CRP, IL-17 decreased significantly, and levels of C3 and C4 increased significantly in two groups (P < 0.05). At the end of treatment, IgA, IgM, IgG, ESR, Scr, 24-hour urinary protein quantification, RHF, CRP, IL-17 in the observation group were significantly lower than those in the control group, while C3 and C4 were significantly higher than those in the control group (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).
      Conclusion  Cyclophosphamide combined with prednisone is effective and safe in treatment of LN, which can improve the immune function and renal function of patients, and reduce the levels of RHF, CRP and IL-17.

     

    • HTML全文
    • 参考文献(22)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回