Objective  To investigate the effect of mucopolysaccharide polysulfate cream combined with zinc oxide ointment on the levels of interferon-γ (IFN-γ), interleukin-4 (IL-4) and interleukin-10 (IL-10) in eczema infants.

  Methods  A total of 80 infants with eczema admitted to our hospital were randomly divided into control group (n=40) and observation group (n=40). The control group was treated with mucopolysaccharide polysulfate cream, while the observation group was treated with mucopolysaccharide polysulfate cream combined with zinc oxide ointment. The levels of IFN-γ, IL-4 and IL-10 before and after treatment were compared between the two groups. The clinical efficacy and the score of clinical symptoms were compared between the two groups.

  Results  There was no significant difference in the levels of IFN-γ, IL-4 and IL-10 between the two groups before treatment (P>0.05). After treatment, the level of IFN-γ in the observation group was higher and levels of IL-4 and IL-10 in the observation group were significantly lower than those in the control group (P < 0.05). The total effective rate in the observation group was higher, and clinical symptom scores in the observation group was better than that in the control group (P < 0.05).

  Conclusion  The therapeutic effect of two ointments for infants with eczema is ideal, which can effectively improve the level of cytokines and the clinical symptoms of children.