Objective   To study the efficacy and safety of methotrexate intramuscular injection combined with oral mifepristone oral administration in the treatment of ectopic pregnancy.

  Methods   A total of 42 patients with ectopic pregnancy in our hospital were selected for the study. According to the random number table method, the patients were divided into control group and observation group, with 21 cases per group. The control group was given intramuscular injection of methotrexate, while the observation group was given mifepristone orally on the basis of the control group. The treatment efficacy, the diameter of mass, blood Blood β-human chorionic gonadotropin (β-HCG) value, hospital stay, menstrual recovery time, disappearance time of abdominal pain and mass, and adverse reactions were observed before and after treatment.

  Results   The total effective rate of the observation group was significantly higher than that of the control group (90.48% vs. 61.90%, P < 0.05). Before treatment, there were no significant differences in the diameter of mass and blood β-HCG between the two groups (P>0.05). After treatment, the above indicators in the observation group were significantly lower than that in the control group(P < 0.05). The hospital stay, menstrual recovery time, disappearance time of abdominal pain and mass were significantly shorter than that in the control group (P < 0.05). The incidence of adverse reactions in the observation group was slightly higher than that in the control group, but there was no significant difference between the two groups (P>0.05).

  Conclusion   Methotrexate injection combined with oral mifepristone, characterized by quick onset and higher safety, has remarkable effect for patients with ectopic pregnancy.