Objective  To investigate the effect of immunotherapy with allergen vaccine in allergic bronchial asthma patients combined with rhinitis.

  Methods  A total of 100 patients with allergic bronchial asthma combined with rhinitis in our hospital were randomly divided into two groups. The control group(n=50) was treated with seretide combined with budesonide nasal spray, while the observation group(n=50) used immunotherapy with allergen vaccine, the therapeutic effects of the two groups were compared.

  Results  The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the asthma control test (ACT) score in the observation group was significantly higher, and the allergic rhinitis symptom scores was significantly lower than that of the control group(P < 0.05). After treatment, the total quality of life in the observation group was significantly higher than that in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

  Conclusion  Allergen vaccine can improve the symptoms of asthma and rhinitis, and improve the quality of life of patients with allergic bronchial asthma complicated with rhinitis. Meanwhile, it has an ideal therapeutic efficacy and higher safety.