Abstract: Objective To explore the effect of hysteroscopic endometrial electrotomy in the treatment of patients with refractory dysfunctional uterine bleeding. Methods A total of 98 patients with refractory dysfunctional uterine bleeding were selected and randomly divided into control group and study group, with 49 cases in each group. Patients in the control group were treated with levonorgestrel intrauterine contraceptive system in the vagina, while patients in the study group were treated with hysteroscopic endometrial electrotomy. The endometrial thickness, menstrual volume, sex hormone indexes ［serum luteinizing hormone(LH), estradiol(E₂), follicle stimulating hormone(FSH)］, hemoglobin level(Hb)and adverse reactions were compared between the two groups before treatment and 6 months after treatment. Results After 6 months of treatment, the endometrial thickness and menstrual volume of the study group were significantly smaller and less than those of the control group(P<0.01). After 6 months of treatment, the levels of LH and FSH in the control group were significantly higher than those in the study group(P<0.01), and the level of E₂ was significantly lower than that in the study group(P<0.01). After 6 months of treatment, the Hb level in the study group was significantly higher than that in the control group(P<0.01). The incidence rate of adverse reactions in the study group was 2.04%, which was significantly lower than 16.33% in the control group(P=0.014). Conclusion Hysteroscopicendometrial electrotomy is effective in the treatment of patients with refractory dysfunctional uterine bleeding, which can not only effectively improve the symptoms of patients, correct the level of Hb, but also has no significant impact on the levels of sex hormones.