Abstract: Objective To investigate the effects of Yiqi Dripping Pills combined with western medicine on hemodynamics, left ventricular filling pressure, serum cystatin(CysC), and B-type natriuretic peptide(BNP)in patients with chronic heart failure(CHF)in vulnerable period. Methods Eighty-three patients with heart failure in the vulnerable period who were admitted to our hospital from February 2017 to April 2019 were randomly divided into observation group(n=42)and control group(n=41). The control group was treated with conventional western medicine, and the observation group was treated with QishenYiqi Dripping Pills on the basis of the control group. After 3 months of treatment, the total effective rate, TCM syndrome efficacy, and hemodynamics ［pulmonary capillary wedge pressure(PCWP), mean pulmonary artery pressure(MPAP)and central venous pressure(CVP)］, left ventricular function indicators ［left ventricular ejection fraction(LVEF), ratio of early(E)and late(A)diastolic filling velocities(E/A)at the tip of mitral valve leaflets, the ratio of E to peak velocity of early diastolic wave of the lateral tricuspid annulus(Ea)(E/Ea)］, levels of serum CysC as well as BNP and adverse reactions were compared. Results After treatment, - the total clinical effective rate and TCM symptom effective rate of the observation group were significantly higher than those of the control group(97.62%, 95.24% vs. 82.93%, 80.49%, respectively, P<0.05). After treatment, PCWP, MPAP, and CVP in both groups were decreased, and the observation group was better than the control group(P<0.05). After treatment, E/A, and E/Ea were decreased in both groups, but LVEF was increased, and the observation group was better than the control group(P<0.05). After treatment, the serum CysC and BNP levels of the two groups decreased, and the observation group was lower than the control group(P<0.05). Within 3 months of treatment, the incidence of adverse reactions was 12.20% in the control group and 14.29% in the observation group, but no significant difference in the incidence of adverse reactions between the two groups was found(P>0.05). The re-hospitalization rate in the observation group was lower than that in the control group(9.52% vs. 26.83%, P<0.05). There was no significant difference in mortality rate between the two groups(2.38% in observation group and 4.88% in the control group, P>0.05). Conclusions Qishen Yiqi Dripping Pills combined with western medicine can improve the hemodynamics, reduce the left ventricular filling pressure, and decrease serum CysC and BNP levels, so it is a safe and effective method for CHF patients in vulnerable period.