Objective  To investigate the clinical significance of serum endothelial cell specific molecule-1 (Endocan-1)and visceral adipose tissue-derived serine proteaseinhibitor (Vaspin) levels in the diagnosis of type 2 diabetes mellitus (T2DM) macroangiopathy (MVC).

  Methods  Seventy-two patients were selected and divided into T2DM group (n=36) and MVC group (n=36) according to whether they were complicated with macrovascular disease. In addition, 36 healthy subjects were selected as control group. The levels of Endocan-1 and Vaspin in serum of the three groups were determined by enzym-linked immunosorbent assay.

  Results  The levels of serum Endocan-1 in T2DM group and MVC group were significantly higher than that in the control group, and the level of serum endocan-1 in MVC group was significantly higher than that in T2DM group (P < 0.05). The level of Vaspin in MCV group was significantly lower than that in T2DM group and control group, and the level of Vaspin in T2DM group was significantly higher than that in control group (P < 0.05). Endocan-1 was positively correlated with T2DM complicated with macrovascular disease, while Vaspin was negatively correlated with T2DM complicated with macrovascular disease. The areas under curve (AUC) of Endocan-1 and Vaspin in MVC group were 0.910% and 0.720%, and the cut-off values were 1 410 pg/mL and 890 pg/mL, respectively. The sensitivity was 81% and 85%, and the specificity was 76% and 73%, respectively.

  Conclusion  Serum Endocan-1 and Vaspin levels are correlated with T2DM macroangiopathy, which can be used as the diagnostic basis for T2DM macroangiopathy.