Abstract: Objective To evaluate the value of growth differentiation factor-15(GDF-15)in predicting risk of acute kidney injury(AKI)in patients with acute coronary syndrome(ACS). Methods Totally 694 ACS patients were enrolled as research objects. Venous blood of all patients were collected at the time of admission. The expression levels of GDF-15 were measured by enzyme-linked immunosorbent assay(ELISA). The patients were divided into experimental group(AKI group, n=81)and control group(non-AKI group, n=613)according occurrence of AKI. GDF-15 levels between the two groups were compared. Multivariate logistic regression analysis was performed to analyze correlation between GDF-15 level and AKI risk during hospitalization in ACS patients. The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of GDF-15 in AKI risk. Results The occurrence of AKI in 694 patients was 11.67%. GDF-15 level at admission in the experimental group was higher than that in the control group ［(1 320.24±281.71)versus(979.88±319.77)ng/L, P<0.05］. High expression of GDF-15 was an independent risk factor of AKI in ACS patients during hospitalization(OR: 1.004, 95% confidence interval(CI): 1.003-1.005, P<0.001). The area under the curves(AUC)of plasma GDF-15 was 0.774, with 95% CI of 0.723 to 0.824. Conclusion High level of GDF-15 is an independent risk factor of AKI in ACS patients, which has a higher predictive value for AKI.