Abstract: Objective To explore the effect of continuous nursing on pain and quality of life of patients with rheumatoid arthritis. Methods A total of 88 patients with rheumatoid arthritis admitted to our hospital were selected, and were divided into observation group and control group according to random number table method. The changes of pain and quality of life were compared between the two groups. Results The proportion of patients with mild pain in the observation group was significantly higher than that in the control group, while the proportion of patients with severe pain was significantly lower than that in the control group(P<0.05). The scores of physical function, social communication function, physiological function, emotional function and mental health in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Continuous nursing can effectively reduce the degree of pain and improve the quality of life of patients with rheumatoid arthritis.