Abstract: Objective To explore the diagnostic value of color Doppler ultrasonography for infants with common acute abdomen. Methods The color Doppler ultrasound data of 200 infants with acute abdomen was analyzed. Taking clinical follow-up, intraoperative exploration or postoperative disease test results as gold standard, the effects of color Doppler ultrasonography in diagnosis of different acute abdominal diseases were observed. Results The gold standard diagnosis results showed intussusception in 11 cases, intestinal obstruction in 35 cases, mesenteric lymphadenitis in 74 cases and acute appendicitis in 80 cases. The ultrasonic diagnosis results showed intussusception in 11 cases, intestinal obstruction in 33 cases, mesenteric lymphadenitis in 74 cases and acute appendicitis in 72 cases, their coincidence rates of intussusception, ileus, mesenteric lymphadenitis and acute appendicitis were 100.00%, 94.29%, 100.00% and 90.00%, respectively. The ultrasonic diagnosis results of intestinal obstruction showed that the coincidence rates of small intestinal obstruction and colon obstruction were 95.83% and 90.91%, respectively. The ultrasonic diagnosis results of acute appendicitis showed that the coincidence rates of simple, suppurative, peripheral abscess and gangrene acute appendicitis were 100.00%, 87.50%, 83.33% and 72.73%, respectively. Conclusion Color Doppler ultrasonography has a good effect in diagnosis of acute abdomen in infants, which provides a basis for clinical treatment.