Abstract: Objective To investigate the effect of cilostazol on hemodynamics and restenosis rate after stent implantation in patients with intracranial small aneurysm. Methods The clinical data of 86 patients with intracranial small aneurysms was retrospectively analyzed. According to whether administration of cilostazol or not during treatment, they were divided into control group and observation group, with 43 cases in each group. Both groups underwent stent implantation. Clinical treatment efficacy, restenosis rate and prognosis were compared, and changes of hemodynamic indicators before anesthesia(T₀), 2 min after anesthesia induction(T₁), 1 min after intubation(T₂), 3 min after intubation(T₃), and 5 min after intubation(T₄)were compared. Results There was no significant difference in effect of tumor embolization between the two groups(P>0.05). There were no significant differences in heart rate(HR), systolic blood pressure(SBP)and diastolic blood pressure(DBP)at T₀ between the two groups(P>0.05). The HR at time points from T₁ to T₄ of the observation group was significantly lower than that in the control group(P<0.05). The blood pressure of the observation group was stable, and their values were significantly lower at time points from T₂ to T₄ than those in the control group and blood pressure was significantly higher at T₁ than that in the control group(P<0.05). The restenosis rate was 2.3% in the observation group, and was significantly lower than 9.3% in the control group(P<0.05). The good rate of the observation group was 81.4%, which was significantly higher than 65.1% in the control group(P<0.05). Conclusion Cilostazol in treating intracranial small aneurysm patients with stent implantation has better clinical effect, which is beneficial to stabilize the hemodynamic status, reduce the rate of restenosis, and obtain a favorable prognosis.