高级检索
蒋威华, 伊丽娜, 张晨光, 雪来提·派祖拉, 许文婷, 欧江华. 三阴性乳腺癌中间质-上皮细胞转化因子及脂肪酸合成酶的表达情况及对预后的影响[J]. 实用临床医药杂志, 2021, 25(8): 16-20. DOI: 10.7619/jcmp.20210355
引用本文: 蒋威华, 伊丽娜, 张晨光, 雪来提·派祖拉, 许文婷, 欧江华. 三阴性乳腺癌中间质-上皮细胞转化因子及脂肪酸合成酶的表达情况及对预后的影响[J]. 实用临床医药杂志, 2021, 25(8): 16-20. DOI: 10.7619/jcmp.20210355
shu
JIANG Weihua, YI Lina, ZHANG Chenguang, Xuelaiti·PAIZULA, XU Wenting, OU Jianghua. Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 16-20. DOI: 10.7619/jcmp.20210355
Citation: JIANG Weihua, YI Lina, ZHANG Chenguang, Xuelaiti·PAIZULA, XU Wenting, OU Jianghua. Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 16-20. DOI: 10.7619/jcmp.20210355
shu

三阴性乳腺癌中间质-上皮细胞转化因子及脂肪酸合成酶的表达情况及对预后的影响

Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis

    摘要
  • 摘要:
      目的  观察间质-上皮细胞转化因子（c-Met）及脂肪酸合成酶（FASN）在三阴性乳腺癌患者中的表达情况及对预后的影响。
      方法  采用免疫组织化学染色法（SP）检测218例三阴性乳腺癌组织及癌旁组织中c-Met及FASN蛋白的表达水平，观察c-Met及FASN阳性表达情况，并探讨其与临床病理特征的关系及对预后的影响。
      结果  218例患者中c-Met阳性表达130例（59.6%），FASN阳性表达142例（65.1%），高于癌旁组织，且c-Met及FASN阳性表达与患者腋窝淋巴结转移情况、TNM分期和组织学分级相关（P < 0.05），但与肿瘤直径无关（P>0.05）。FASN阳性表达与糖尿病及体质量指数相关。生存分析显示，三阴性乳腺癌患者c-Met及FASN阳性表达患者的5年无瘤生存期短于阴性表达患者（P < 0.05）。
      结论  c-Met及FASN阳性表达参与了三阴性乳腺癌的侵袭、发展、复发及转移过程，可作为判断三阴性乳腺癌预后不良的生物学指标。

     

    Abstract:
      Objective  To observe the expression of mesenchymal-epithelial transition factor (c-Met) and fatty acid synthase(FASN) in patients with triple-negative breast cancer, and their impacts on prognosis.
      Methods  Immunohistochemical staining (SP) method was used to detect the expression levels of c-Met and FASN protein in 218 cases of triple-negative breast cancer tissues and adjacent tissues, and the relationships between positive expression of c-Met, FASN and clinicopathological characteristics as well as their impacts on prognosis.
      Results  Among 218 patients, 130 cases (59.6%) had positive c-Met expression, and 142 cases (65.1%) had FASN positive expression, which were significantly higher than those of the adjacent tissues, and the positive expression levels of c-Met and FASN were correlated with axillary lymph node metastasis, TNM staging and histological grading (P < 0.05). However, they were not correlated with tumor diameter (P>0.05). Positive expression of FASN was also related to diabetes and body mass index. Survival analysis showed that the five-year tumor-free survival of triple negative breast cancer patients with positive expression of c-Met and FASN protein was significantly shorter than those of negative expression ones (P < 0.05).
      Conclusion  The positive expression of c-Met and FASN is involved in the invasion, development, recurrence and metastasis of triple-negative breast cancer, and can be used as one of the biological indicators to judge the poor prognosis of triple-negative breast cancer.

     

    • HTML全文
    • 参考文献(24)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回