成纤维细胞生长因子-21与2型糖尿病及血管并发症关联性研究进展

Research advance in correlations between fibroblast growth factor-21 and occurrence as well as development of vascular complications of type 2 diabetes mellitus

摘要: 2型糖尿病（T2DM）是常见的慢性代谢性疾病，慢性并发症尤其是血管并发症是其主要危害。成纤维细胞生长因子-21（FGF-21）作为近年来新发现的代谢调节因子，被认为与T2DM的发生及糖尿病并发症的发生、发展密切相关。本文对FGF-21与糖尿病微血管并发症及大血管并发症相关研究进展进行综述。FGF-21作为糖尿病血管并发症的生物标志物或治疗靶点的作用值得进一步研究，对于T2DM血管并发症的预测具有重要价值。

Abstract: Type 2 diabetes(T2DM) is a common chronic metabolic disease, and its chronic complications, especially vascular complications, are the main damages of T2DM. Fibroblast growth factor-21(FGF-21) is a newly discovered metabolism regulator, which is considered to be closely linked to the development of T2DM and its complications. We summarized relevant studies about FGF-21 in vascular and macrovascular complications of T2DM. The role of FGF-21 as a biomarker or therapeutic target for vascular complications of T2DM requires further investigations, and its application in predicting vascular complications of T2DM has significant value.