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夏青, 厉虹淼, 侯婧. 结核感染T细胞斑点试验对老年肺结核的诊断价值[J]. 实用临床医药杂志, 2021, 25(16): 18-21. DOI: 10.7619/jcmp.20212162
引用本文: 夏青, 厉虹淼, 侯婧. 结核感染T细胞斑点试验对老年肺结核的诊断价值[J]. 实用临床医药杂志, 2021, 25(16): 18-21. DOI: 10.7619/jcmp.20212162
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XIA Qing, LI Hongmiao, HOU Jing. Diagnostic value of T-spot test for tuberculosis infection in elderly patients with pulmonary tuberculosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(16): 18-21. DOI: 10.7619/jcmp.20212162
Citation: XIA Qing, LI Hongmiao, HOU Jing. Diagnostic value of T-spot test for tuberculosis infection in elderly patients with pulmonary tuberculosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(16): 18-21. DOI: 10.7619/jcmp.20212162
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结核感染T细胞斑点试验对老年肺结核的诊断价值

Diagnostic value of T-spot test for tuberculosis infection in elderly patients with pulmonary tuberculosis

    摘要
  • 摘要:
      目的   探讨结核感染T细胞斑点试验(T-SPOT. TB)对老年肺结核的诊断价值。
      方法   随机选取老年非结核患者(≥60岁)70例、老年肺结核患者(≥60岁)70例、中青年肺结核患者(21~59岁)70例分别纳入老年非结核组、老年肺结核组、中青年肺结核组，比较3组患者T-SPOT. TB、结核菌素(PPD)试验、血清结核抗体(TB-Ab)检测的阳性率。
      结果   老年肺结核组、中青年肺结核组的T-SPOT. TB阳性率均高于老年非结核组，差异有统计学意义(P < 0.05); 老年肺结核组的T-SPOT. TB阳性率与中青年肺结核组比较，差异无统计学意义(P>0.05)。老年肺结核组的PPD阳性率低于中青年肺结核组，差异有统计学意义(P < 0.05); 老年肺结核组、中青年肺结核组的TB-Ab阳性率比较，差异无统计学意义(P>0.05)。老年肺结核组中, T-SPOT. TB的阳性率高于PPD试验、TB-Ab检测，差异有统计学意义(P < 0.05)。
      结论   T-SPOT. TB在老年肺结核的诊断中作用显著，阳性率较高。

     

    Abstract:
      Objective   To investigate the diagnostic value of T-spot. TB test(T-SPOT. TB) in diagnosing tuberculosis in elderly patients with pulmonary tuberculosis.
      Methods   A total of 70 elderly (≥ 60 years old) non-tuberculosis patients, 70 elderly (≥ 60 years old) tuberculosis patients and 70 middle-aged and young (ranging from 21 to 59 years old) tuberculosis patients were included in elderly non-tuberculosis group, elderly tuberculosis group, young and middle-aged tuberculosis group, respectively. The positive rates of T-SPOT. TB, purified protein derivative (PPD) tuberculin test and TB antibody (TB-Ab) test were compared among three groups.
      Results   The positive rates of T-SPOT. TB in elderly tuberculosis group as well as young and middle-aged tuberculosis group were higher than those in elderly non-tuberculosis group (P < 0.05), but there was no significant difference between the elderly tuberculosis group and the young and middle-aged tuberculosis group (P>0.05). The PPD positive rate in the elderly tuberculosis group was lower than that in the young and middle-aged group (P < 0.05). There was no significant difference in the positive rate of TB-Ab between the elderly tuberculosis group and the young and middle-aged group (P>0.05). In elderly tuberculosis group, the positive rate of T-SPOT. TB was significantly higher than that of PPD and TB-Ab tests(P < 0.05).
      Conclusion   T-SPOT. TB plays a significant role in the diagnosis of senile pulmonary tuberculosis, and has a high positive rate.

     

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