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黄剑吟, 杨焱平, 黄冠东, 杨开超, 仲伟喜, 封启明. 骨折后血清骨钙素N端中分子片段与糖代谢指标的相关性分析[J]. 实用临床医药杂志, 2022, 26(1): 80-84. DOI: 10.7619/jcmp.20212356
引用本文: 黄剑吟, 杨焱平, 黄冠东, 杨开超, 仲伟喜, 封启明. 骨折后血清骨钙素N端中分子片段与糖代谢指标的相关性分析[J]. 实用临床医药杂志, 2022, 26(1): 80-84. DOI: 10.7619/jcmp.20212356
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HUANG Jianyin, YANG Yanping, HUANG Guandong, YANG Kaichao, ZHONG Weixi, FENG Qiming. Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 80-84. DOI: 10.7619/jcmp.20212356
Citation: HUANG Jianyin, YANG Yanping, HUANG Guandong, YANG Kaichao, ZHONG Weixi, FENG Qiming. Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 80-84. DOI: 10.7619/jcmp.20212356
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骨折后血清骨钙素N端中分子片段与糖代谢指标的相关性分析

Correlation between serum N-terminal mid-fragment of osteocalcin and index of glucose metabolism after fracture

    摘要
  • 摘要:
      目的  探讨骨折后血清骨钙素N端中分子片段(N-MID OC)与糖化血红蛋白(HbA1c)、空腹血糖(FPG)、空腹胰岛素(FINS)、C-肽(C-P)的相关性。
      方法  采用回顾性研究方法, 将196例单一闭合性骨折男性患者纳入骨折组，将64例健康男性纳入健康对照组，比较2组的一般资料和生化指标水平。将骨折患者按N-MID OC四分位数分为4个亚组，比较4组患者HbA1c、FPG、FINS、C-P水平。分析血清N-MID OC水平与糖代谢指标及生化指标的相关性。
      结果  骨折组年龄、体质量指数、血肌酐、HbA1c与健康对照组比较，差异无统计学意义(P>0.05); 骨折组白细胞、谷丙转氨酶、谷草转氨酶、FPG、FINS、C-P水平高于健康对照组，血小板、血红蛋白、钙离子、25-羟维生素D3和N-MID OC水平低于健康对照组，差异有统计学意义(P < 0.05)。不同亚组骨折患者的年龄和血小板、FPG、N-MID OC水平比较，差异有统计学意义(P < 0.05)。相关性分析显示, N-MID OC与年龄(r=-0.280, P < 0.001)、HbA1c(r=-0.081, P=0.011)、FPG(r=-0.196, P=0.006)均呈负相关; 调整年龄因素后，多元线性回归分析显示, FPG是单一闭合性骨折患者血清N-MID OC的独立影响因素(β=-0.147, P=0.036, 95%CI为-0.663~-0.023)。
      结论  骨折创伤后糖代谢与血清N-MID OC存在相关性，这可能是影响骨代谢的因素。

     

    Abstract:
      Objective  To investigate the relationships between serum N-terminal mid-fragment of osteocalcin (N-MID OC) and hemoglobin A1c(HbA1c), fasting plasma glucose(FPG), fasting insulin (FINS) and C-peptide (C-P).
      Methods  A total of 196 male patients with single closed fracture were included in fracture group and 64 healthy men in healthy control group based on a retrospective study method, and the general data and biochemical indexes of the two groups were compared. The fracture patients were divided into four subgroups according to N-MID OC quartile, and the levels of HbA1c, FPG, FINS and C-P in four groups were compared. The correlations of serum N-Mid OC level with glucose metabolism and biochemical indexes were analyzed.
      Results  There were no differences in age, body mass index, serum creatinine and HbA1c between the fracture group and the healthy control group (P>0.05). Leukocyte, alanine aminotransferase, aspartate aminotransferase, FPG, FINS, C-P in the fracture group were higher than those in the healthy control group, while platelets, hemoglobin, calcium ions, the levels of 25-hydroxyvitamin D3 and N-MID OC levels were lower than those of the healthy control group (P < 0.05). There were significant differences in age, platelets, FPG, and N-MID OC in the subgroups (P < 0.05). Correlation analysis showed that serum N-MID OC was negatively correlated with age (r=-0.280, P < 0.001), HbA1c(r=-0.081, P=0.011) and FPG(r=-0.196, P=0.006). After adjusting for age factor, multiple linear regression analysis showed that FPG was an independent factor affecting serum N-MID OC of patients with single closed fracture(β=-0.147, P < 0.001, 95%CI, -0.663 to -0.023).
      Conclusion  There is a correlation between glucose metabolism and serum N-MID OC after fracture, which may be a factor affecting bone metabolism.

     

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