血清缺氧诱导因子-1α、肾上腺髓质素前体、甘胆酸水平与老年慢性阻塞性肺疾病急性加重期患者肺功能损伤进展的相关性

蒋和平; 王劢; 吴国荣; 王丽东

doi:10.7619/jcmp.20213545

血清缺氧诱导因子-1α、肾上腺髓质素前体、甘胆酸水平与老年慢性阻塞性肺疾病急性加重期患者肺功能损伤进展的相关性

Correlations of serum hypoxia inducible factor-1α, pro-adrenomedullin and glycocholic acid levels with progress of lung function injury in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

摘要

摘要:
目的探讨血清缺氧诱导因子-1α（HIF-1α）、肾上腺髓质素前体（pro-ADM）、甘胆酸（CG）水平与老年慢性阻塞性肺疾病急性加重期（AECOPD）患者肺功能损伤进展的相关性。
方法前瞻性选取91例AECOPD患者为研究对象。入院时检测患者的血清HIF-1α、pro-ADM、CG水平，治疗后随访1年。统计患者肺功能损伤情况，将其分为肺功能损伤加重组（n=23）和肺功能损伤未加重组（n=68）。分析血清HIF-1α、pro-ADM、CG水平与AECOPD患者肺功能损伤加重的相关性。
结果 AECOPD患者肺功能损伤加重患者占25.27%；肺功能损伤加重组血清HIF-1α、pro-ADM、CG水平高于肺功能损伤未加重组，差异有统计学意义（P < 0.05）。血清HIF-1α、pro-ADM、CG表达水平高是AECOPD患者肺功能损伤加重的影响因素（OR>1，P < 0.05）。血清HIF-1α、pro-ADM、CG水平预测AECOPD患者肺功能损伤加重风险的曲线下面积（AUC）均>0.80。
结论血清HIF-1α、pro-ADM、CG表达水平高可能与老年AECOPD患者肺功能损伤加重相关。早期检测血清HIF-1α、pro-ADM、CG水平可预测老年AECOPD患者肺功能损伤情况。

Abstract:
Objective To investigate the correlations of serum hypoxia inducible factor-1α (HIF-1α), pro-adrenomedullin (pro-ADM) and glycocholic acid (CG) levels with progress of lung function injury in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods Ninety-one patients with AECOPD were prospectively selected as research subjects. Serum HIF-1α, pro-ADM and CG levels were detected on admission, and followed up for one year after treatment. Patients with lung function injury were counted and divided into lung function injury exacerbation group (n=23) and lung function injury without exacerbation group (n=68). The correlations of serum HIF-1α, pro-ADM and CG levels with exacerbation of lung function injury in patients with AECOPD were analyzed.
Results The proportion of exacerbation of lung function injury in AECOPD patients was 25.27%; the serum HIF-1α, pro-ADM and CG levels of the lung function injury exacerbation group were significantly higher than those of the lung function injury without exacerbation group (P < 0.05). The high expression levels of serum HIF-1α, Pro-ADM and CG were the influencing factors for the exacerbation of lung function injury in patients with AECOPD (OR>1, P < 0.05). The area under the curve (AUC) of serum HIF-1α, pro-ADM and CG levels predicting the risk of exacerbating lung function injury in AECOPD patients were all greater than 0.80.
Conclusion The high expression levels of serum HIF-1α, pro-ADM and CG may be associated with the exacerbation of lung function injury in elderly patients with AECOPD. Early detection of serum HIF-1α, pro-ADM and CG levels can predict lung function injury in elderly patients with AECOPD.

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