Abstract: Acute respiratory distress syndrome (ARDS),with high mortality,is a clinical syndrome characterized by intractable hypoxemia induced by internal and external causes.However,the diagnosis mainly depends on clinical diagnosis and lacks specific test,which is often ignored.The use of biomarkers can provide important insights into the pathophysiological mechanism of ARDS and contribute to diagnosis,risk stratification and identification of candidate treatment targets.This study summarized the research progress of biomarkers in the clinical application of ARDS in recent years,and discussed its future research direction and prospects,in order to provide theoretical support for precision medicine in ARDS management.