Objective To explore the correlations of anxiety and depression with quality of life in patients with atrial fibrillation, and to evaluate the effects of different anticoagulant therapies on emotions of patients with atrial fibrillation.

Methods A total of 86 patients with atrial fibrillation were conducted with questionnaire surveys in anxiety, depression and quality of life.The patients were divided into anxiety group (n=22) and non-anxiety group (n=64), and were divided into depression group (n=28) and non-depression group (58 cases) afterwards.The scores of physical function (PF), physical role (RP), body pain (BP), general health (GH), vitality (VT), social function (SF), role emotion (RE) and mental health (MH) in the anxiety group and depression group were separately and significantly lower than those in the non-anxiety group and non-depression group (P < 0.05).Patients taking warfarin were more likely to have anxiety, and taking new oral anticoagulants could effectively alleviate anxiety and depression.Spearman correlation analysis showed that there were no correlations of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) with quality of life (P>0.05).

Conclusion Atrial fibrillation patients with anxiety or depression have heavier symptom burden and worse quality of life, and taking new oral anticoagulants can help to improve patients′anxiety and depression.