组蛋白甲基化修饰在衰老性心血管病变中的研究进展

Research progress on histone methylation modification in aging cardiovascular disease

摘要: 关注心肌衰老、瓣膜改变、心脏传导系统改变及血管老化等心脏结构和功能的改变，对研究衰老相关心血管疾病的治疗方法至关重要。组蛋白甲基化修饰参与调控基因表达，与衰老性心血管疾病的发生发展密切相关。本文就组蛋白甲基化修饰在心脏结构和功能改变中的作用进行综述，为衰老性心血管病变的研究提供新的理论依据。

Abstract: Changes in cardiac structure and function such as myocardial aging, valve alterations, alterations in the cardiac conduction system and vascular aging are crucial for studying therapeutic methods for age-related cardiovascular diseases. Histone methylation modification is involved in the regulation of gene expression and closely related to the occurrence and development of age-related cardiovascular diseases. This paper provided a comprehensive review on the role of histone methylation modification in cardiac structural and functional changes, providing new theoretical basis for age-related cardiovascular diseases.