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杨麒臻, 牛玉林, 陈乾. 基于生物信息学分析γ-谷氨酰转移酶5在肝癌中的表达和意义[J]. 实用临床医药杂志, 2023, 27(19): 32-39. DOI: 10.7619/jcmp.20232877
引用本文: 杨麒臻, 牛玉林, 陈乾. 基于生物信息学分析γ-谷氨酰转移酶5在肝癌中的表达和意义[J]. 实用临床医药杂志, 2023, 27(19): 32-39. DOI: 10.7619/jcmp.20232877
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YANG Qizhen, NIU Yulin, CHEN Qian. Expression and significance of gamma-glutamyl transferase 5 in hepatocellular carcinoma based on bioinformatics analysis[J]. Journal of Clinical Medicine in Practice, 2023, 27(19): 32-39. DOI: 10.7619/jcmp.20232877
Citation: YANG Qizhen, NIU Yulin, CHEN Qian. Expression and significance of gamma-glutamyl transferase 5 in hepatocellular carcinoma based on bioinformatics analysis[J]. Journal of Clinical Medicine in Practice, 2023, 27(19): 32-39. DOI: 10.7619/jcmp.20232877
shu

基于生物信息学分析γ-谷氨酰转移酶5在肝癌中的表达和意义

Expression and significance of gamma-glutamyl transferase 5 in hepatocellular carcinoma based on bioinformatics analysis

    摘要
  • 摘要:
    目的 探讨γ-谷氨酰转移酶5(GGT5)在肝细胞癌(HCC)中的表达，分析其与预后及免疫浸润的相关性。
    方法 通过TCGA、HPA、TIMER在线网站分析GGT5在HCC组织中的蛋白和基因表达水平。使用UALCAN数据库分析GGT5与临床特征的相关性。使用Kaplan-Meier分析探讨GGT5表达水平对HCC患者预后的影响。使用Linked Omics数据库分析与GGT5相关及共表达的基因。使用基因本体论(GO)、京都基因和基因组百科全书(KEGG)数据评估GGT5参与相关生物学的过程和信号通路。通过TIMER在线网站分析GGT5与肿瘤免疫浸润的相关性。
    结果 与邻近的癌旁组织相比, GGT5在肝癌组织中的表达降低, GGT5的低表达与肿瘤分期显著相关。GGT5低表达的HCC患者的总生存期(OS)较短。功能分析表明, GGT5参与肝癌细胞的蛋白酶体重组。GGT5低表达与免疫细胞浸润水平呈正相关。
    结论 GGT5与HCC的预后和免疫浸润有关，可能是HCC的潜在治疗靶点。

     

    Abstract:
    Objective To explore the expression of gamma-glutamyl transferase 5 (GGT5) in hepatocellular carcinoma (HCC) and analyze its correlations with prognosis and immune infiltration.
    Methods The protein and gene expression levels of GGT5 in HCC tissues were analyzed by TCGA, HPA and TIMER online websites. The UALCAN database was used to analyze the correlation of GGT5 with clinical features. The Kaplan-Meier analysis was used to explore the influence of GGT5 expression level on the prognosis of HCC patients. The Linked Omics database was used to explore GGT5-associated genes and co-expressed genes. Involvement of GGT5 in related biological processes and signaling pathways were evaluated by data from Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The correlation between GGT5 and tumor immune infiltration was evaluated by TIMER online website.
    Results Compared with adjacent paracancerous tissues, the expression of GGT5 was reduced in liver cancer tissues, and the low expression of GGT5 was significantly correlated with tumor staging. HCC patients with low GGT5 expression had a shorter overall survival (OS). Functional analysis showed that GGT5 was involved in proteasomal reorganization in liver cancer cells. The low expression of GGT5 was positively correlated with the level of immune cell infiltration.
    Conclusion GGT5 is associated with prognosis and immune infiltration in HCC, and it may be a potential therapeutic target for HCC.

     

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