结直肠癌组织中核受体视黄酸X受体a及核受体相互作用蛋白1的表达与预后的关系

陈易华; 罗艳; 田强; 曾冬梅; 许雷

doi:10.7619/jcmp.20233683

结直肠癌组织中核受体视黄酸X受体a及核受体相互作用蛋白1的表达与预后的关系

Relationships of retinoid X receptor alpha and nuclear receptor interaction protein 1 expressions with prognosis in colorectal cancer

摘要

摘要:
目的分析结直肠癌组织中核受体视黄酸X受体a(RXRA)、核受体相互作用蛋白1(NRIP1)表达与患者临床病理特征、预后的关系。
方法将2018年8月—2020年8月本院收治的106例结直肠癌患者手术过程中取得的癌组织标本纳入结直肠癌组(n=106), 对应癌旁组织标本纳入癌旁组(n=106)。应用免疫组化法检测RXRA、NRIP1表达情况。采用多因素Cox回归分析探讨RXRA、NRIP1表达对结直肠癌患者预后的影响。
结果结直肠癌组RXRA、NRIP1的阳性表达率分别为66.04%、69.81%, 高于癌旁组的33.96%、30.19%, 差异均有统计学意义(P < 0.05)。病理分期为Ⅲ期、低分化、有浆膜浸润、有淋巴结转移患者的RXRA阳性表达率、NRIP1阳性表达率高于病理分期为Ⅱ期、中高分化、无浆膜浸润、无淋巴结转移患者，差异有统计学意义(P < 0.05)。病理分期为Ⅱ期、低分化、无浆膜浸润、无淋巴结转移、RXRA阴性、NRIP1阴性患者的3年总生存率高于病理分期为Ⅲ期、中高分化、有浆膜浸润、有淋巴结转移、RXRA阳性、NRIP1阳性患者，差异有统计学意义(P < 0.05)。多因素Cox回归分析显示，有浆膜浸润(HR=2.687, 95%CI: 1.531~3.156)、RXRA阳性(HR=3.743, 95%CI: 2.217~5.992)和NRIP1阳性(HR=2.641, 95%CI: 1.124~4.757)是结直肠癌患者预后的影响因素(P < 0.05)。
结论 RXRA、NRIP1在结直肠癌中呈高表达，与肿瘤分期、分化及转移密切相关，可作为辅助评估患者预后的生物标记物。

Abstract:
Objective To analyze the relationships of the expression of retinoid X receptor alpha (RXRA) and nuclear receptor interaction protein 1(NRIP1) in colorectal cancer tissues with the features of clinical pathology and prognosis.
Methods A total of 106 specimens from colorectal cancer tissues of patients during surgery were included in colorectal cancer group (n=106), and corresponding paracancer tissue specimens were included in paracancer group (n=106). The expressions of RXRA and NRIP1 in colorectal cancer tissues were detected by immunohistochemistry. Multivariate Cox regression analysis was used to investigate th4e effects of RXRA and NRIP1 expressions on the prognosis of patients with colorectal cancer.
Results The positive expression rates of RXRA and NRIP1 in colorectal cancer group were 66.04%, 69.81%, which were significantly higher than 33.96% and 30.19% in the para-cancer group (P < 0.05). The positive expression rates of RXRA and NRIP1 in patients with pathological stage Ⅲ, low differentiation, serous infiltration and lymph node metastasis were higher than those in patients with pathological stage Ⅱ, medium and high differentiation, no serous infiltration and lymph node metastasis (P < 0.05). The 3-year overall survival rates of patients with pathological stage Ⅱ, low differentiation, no serous infiltration, no lymph node metastasis, negative RXRA and NRIP1 were higher than those of patients with pathological stage Ⅲ, medium and high differentiation, serous infiltration, lymph node metastasis, positive RXRA and NRIP1 (P < 0.05). Multivariate Cox regression analysis showed serous membrane infiltration (HR=2.687; 95%CI, 1.531 to 3.156), positive RXRA (HR=3.743; 95%CI, 2.217 to 5.992), positive NRIP1 (HR=2.641; 95%CI, 1.124 to 4.757) were influencing factors for prognosis in patients with colorectal cancer (P < 0.05).
Conclusion RXRA and NRIP1 are highly expressed in colorectal cancer, which are closely related to pathological stage, differentiation degree and metastasis, which can be used as biomarkers to assist in evaluating the prognosis of patients.

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