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李娟娟, 林雁, 王卫平. 三维能量多普勒超声参数联合胎盘生长因子对早发型胎儿生长受限的预测价值[J]. 实用临床医药杂志, 2024, 28(10): 13-16, 23. DOI: 10.7619/jcmp.20234096
引用本文: 李娟娟, 林雁, 王卫平. 三维能量多普勒超声参数联合胎盘生长因子对早发型胎儿生长受限的预测价值[J]. 实用临床医药杂志, 2024, 28(10): 13-16, 23. DOI: 10.7619/jcmp.20234096
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LI Juanjuan, LIN Yan, WANG Weiping. Value of three-dimensional energy Doppler ultrasound parameters combined with placental growth factor in predicting early-onset fetal growth restriction[J]. Journal of Clinical Medicine in Practice, 2024, 28(10): 13-16, 23. DOI: 10.7619/jcmp.20234096
Citation: LI Juanjuan, LIN Yan, WANG Weiping. Value of three-dimensional energy Doppler ultrasound parameters combined with placental growth factor in predicting early-onset fetal growth restriction[J]. Journal of Clinical Medicine in Practice, 2024, 28(10): 13-16, 23. DOI: 10.7619/jcmp.20234096
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三维能量多普勒超声参数联合胎盘生长因子对早发型胎儿生长受限的预测价值

Value of three-dimensional energy Doppler ultrasound parameters combined with placental growth factor in predicting early-onset fetal growth restriction

    摘要
  • 摘要:
    目的  探讨三维能量多普勒超声参数联合胎盘生长因子(PLGF)对早发型胎儿生长受限(FGR)的预测价值。
    方法  选取早发型FGR孕妇80例为FGR组，另选取同期产检健康孕妇50例为对照组。在孕11~13周+6对所有研究对象进行三维能量多普勒超声检查, 收集胎盘容积(PV)、血管化指数(VI)、血流指数(FI)、血管化-血流指数(VFI)等指标。在孕14~16周+6检测所有研究对象血清PLGF水平。
    结果  FGR组的PV、VI、FI、VFI以及血清PLGF水平均低于对照组，差异有统计学意义(P＜0.05)。多元Logistic回归方程分析显示, PV、VI、FI、VFI以及血清PLGF水平过低是早发型FGR的危险因素(P＜0.05)。受试者工作特征(ROC)曲线分析显示, PV、VI、VFI以及血清PLGF均对早发型FGR有一定的预测价值，曲线下面积分别为0.723(95%CI: 0.629~0.817)、0.776(95%CI: 0.693~0.860)、0746(95%CI: 0.653~0.839)、0.799(95%CI: 0.713~0.884), FI对早发型FGR的预测价值一般，曲线下面积为0.625(95%CI: 0.524~0.725)。经分析显示, PLGF联合VI以及PLGF联合VFI对早发型FGR的预测价值较好, PLGF联合VI的敏感度、特异度和约登指数分别为86.25%、76.00%、0.623, PLGF联合VFI的敏感度、特异度和约登指数分别为81.25%、80.00%、0.613。
    结论  三维能量多普勒超声参数联合PLGF对早发型FGR有一定的预测价值，可用于临床筛查早发型FGR高风险人群。

     

    Abstract:
    Objective  To explore the value of three-dimensional energy Doppler ultrasound parameters combined with placental growth factor (PLGF) in predicting early-onset fetal growth restriction (FGR).
    Methods  Eighty pregnant women with early-onset FGR were selected as FGR group, and another 50 healthy pregnant women with prenatal examination were selected as control group. Three-dimensional energy Doppler ultrasonography was performed for all subjects at 11 to 13 weeks plus 6 days of gestation, and placental volume (PV), vascularization index (VI), flow index (FI) and vascularization-flow index (VFI) were collected. Serum PLGF level was measured in all subjects at 14 to 16 weeks plus 6 days of gestation.
    Results  The PV, VI, FI, VFI and serum PLGF level in the FGR group were significantly lower than those in the control group (P < 0.05). Multiple Logistic regression analysis showed that low PV, VI, FI and VFI as well as serum PLGF level were risk factors for early-onset FGR (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that PV, VI, VFI and serum PLGF had certain predictive value for early-onset FGR, with areas under the curve of 0.723 (95%CI, 0.629 to 0.817), 0.776 (95%CI, 0.693 to 0.860), 0.746 (95%CI, 0.653 to 0.839) and 0.799 (95%CI, 0.713 to 0.884) respectively. The predictive value of FI for early-onset FGR was moderate, with an area under the curve of 0.625 (95%CI, 0.524 to 0.725). Analysis showed that the combination of PLGF and VI as well as PLGF and VFI had good predictive values for early-onset FGR, the sensitivity, specificity and Youden index of PLGF combined with VI were 86.25%, 76.00% and 0.623 respectively, while those of PLGF combined with VFI were 81.25%, 80.00% and 0.613 respectively.
    Conclusion  The combination of three-dimensional energy Doppler ultrasound parameters and PLGF has certain predictive value for early-onset FGR, and can be used for clinical screening of high-risk populations with early-onset FGR.

     

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