Abstract: Coronavirus disease 2019 (COVID-19) can induce coagulation dysfunction in patients and is associated with an increased risk of thrombotic complications, including microvascular thrombosis, venous thromboembolism, and stroke. In patients undergoing maintenance hemodialysis, the risk of COVID-19-related coagulation dysfunction and thrombotic complications is further elevated. This article reviewed the pathogenesis of COVID-19-related hypercoagulability and thrombotic complications in patients undergoing maintenance hemodialysis, aiming to provide a reference for the diagnosis and treatment of this disease.