小剂量卡介苗膀胱腔内灌注预防膀胱癌术后复发

PREVENTION OF POSTOPERATIVE BLADDER CANCER RECURRENCE WITH INTRA-BLADDER PERFUSION OF SMALL DOSAGE OF BCG VACCINE

摘要: 目的 :应用小剂量卡介苗 (BCG)行膀胱腔内灌注预防膀胱癌术后复发 ,观察其疗效及减少卡介苗应用中副作用的发生。方法 :对术后 167例浅表性膀胱癌应用 5mg卡介苗行膀胱腔内灌注。结果 :经临床应用证实肿瘤复发率为 16 7%。同时并发症明显减少。结论 :小剂量卡介苗膀胱内灌注疗效确切 ,能明显减少副作用。同时也为延长疗程提供了条件

Abstract: Objective:Intra-bladder perfusion of small dosage of BCG vaccine was applied in the prevention of postoperation bladder cancer recurrence.The result of the method and decrease of side reaction caused by it were investigated.Methods:5mg of BCG vaccine were poured into the bladder after operation in 167 patients who were diagnosed as superficial bladder cancer.Results:After clinical application and follow-up,the recurrence rate was 16 7%.The result was obvious and the complication decreased remarkably.Conclusion:The application of intra-bladder perfusion of small dosage of BCG vaccine will not decrease the clinical result and can decrease the side reaction remarkably so that prolong the treatment period.It is a good method,which needs advanced investigation.