| Citation: |
ZHANG Junfeng, SU Shaohong. Prediction of serum indexes of major adverse cardiovascular events in acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2023, 27(23): 31-36, 42. DOI: 10.7619/jcmp.20231702
|
To analyze the predictive value of serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular intercellular adhesion molecule-1 (sVCAM-1) and soluble microfiber associated protein 4 (sMFAP4) for major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in acute myocardial infarction.
A total of 166 patients with acute myocardial infarction after PCI were included in case group, and 166 healthy volunteers were included in control group during the same period. Enzyme-linked immunosorbent assay was used to detect serum levels of sICAM-1, sVCAM-1 and sMFAP4, and the differences between groups were compared. After being followed-up for 1 year, the case group was divided into MACE group (n=42) and non-MACE (n=113) group after removing 10 cases. General information was compared between the MACE group and the non-MACE group. Logistic regression analysis was used to identify the influencing factors for MACE; receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was used to evaluate the efficacy of relevant indicators in predicting MACE.
The incidence of MACE was 27.10%. The serum levels of sICAM-1, sVCAM-1 and sMFAP4 in the case group were significantly higher than those in the control group, and those in the MACE group were significantly higher than those in the non-MACE group (P < 0.05). Smoking history (OR=3.688, 95%CI, 1.107 to 12.286), drinking history (OR=3.364, 95%CI, 1.238 to 9.139), combined hypertension (OR=4.255, 95%CI, 1.250 to 14.483), combined type 2 diabetes (OR=4.208, 95%CI, 1.051 to 16.856), combined hyperlipidemia (OR=5.238, 95%CI, 1.440 to 19.061), Gensini score (OR=5.579, 95%CI, 1.355 to 22.968), blood platelet count (PLT) (OR=0.519, 95%CI, 0.281 to 0.961), serum sICAM-1 (OR=5.013, 95%CI, 1.859 to 13.514), sVCAM-1 (OR=4.826, 95%CI, 1.769 to 13.164) as well as sMFAP4 (OR=4.745, 95%CI, 1.372 to 16.407) and no reflow during surgery (OR=2.962, 95%CI, 1.107 to 7.924), no collateral circulation formation (OR=3.225, 95%CI, 1.173 to 8.867) were all influencing factors for the occurrence of MACE. Serum sICAM-1, sVCAM-1 and sMFAP4 levels predicted the cut-off value of MACE in the case group were 331.53 ng/mL, 473.20 ng/mL and 30.63 U/L, respectively, the sensitivity was 80.95%, 76.19% and 78.57%, respectively, the specificity was 94.69%, 97.35%, 88.50%, respectively, and the AUC was 0.835 (95%CI, 0.767 to 0.890), 0.794 (95%CI, 0.722 to 0.855), 0.824(95%CI, 0.754 to 0.880), respectively. The sensitivity, specificity and AUC of serum sICAM-1, sVCAM-1 and sMFAP4 to predict MACE were larger or higher than those of Gensini score (P < 0.05); the sensitivity, specificity and AUC of the above serum indexes combined to predict the occurrence of MACE in the case group were 100.00%, 94.69% and 0.956 (95%CI, 0.910 to 0.982), respectively, and the sensitivity and AUC of the combined prediction were higher or larger than those of the single prediction (P < 0.05).
Serum sICAM-1, sVCAM-1 and sMFAP4 levels are increased in patients with acute myocardial infarction, all of which are related to MACE after PCI. The MACE prediction value of the three is better than Gensini score, and the combined prediction value of the three is higher.
| [1] |
LIANG F, WANG Y. Coronary heart disease and atrial fibrillation: a vicious cycle[J]. Am J Physiol Heart Circ Physiol, 2021, 320(1): H1-H12. doi: 10.1152/ajpheart.00702.2020
|
| [2] |
曾维斌, 吴爱梅, 蒋佳莉, 等. 急性心肌梗死患者PCI术后1年发生主要心血管事件的影响因素及预测模型构建[J]. 中国老年学杂志, 2022, 42(20): 4905-4908. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202220001.htm
|
| [3] |
MARCUS G, FARKOUH M E, MINHA S, et al. Association of polycythemia with outcomes of acute coronary syndrome[J]. Cardiology, 2021, 146(6): 720-727. doi: 10.1159/000519468
|
| [4] |
LONGATO E, FADINI G P, SPARACINO G, et al. A deep learning approach to predict diabetes' cardiovascular complications from administrative claims[J]. IEEE J Biomed Health Inform, 2021, 25(9): 3608-3617. doi: 10.1109/JBHI.2021.3065756
|
| [5] |
MEYERSOHN N M, MAYRHOFER T, COREY K E, et al. Association of hepatic steatosis with major adverse cardiovascular events, independent of coronary artery disease[J]. Clin Gastroenterol Hepatol, 2021, 19(7): 1480-1488, e14. doi: 10.1016/j.cgh.2020.07.030
|
| [6] |
吕晓, 李树仁, 李文静, 等. 急性非ST段抬高型心肌梗死患者远期不良心血管事件危险因素筛选及预测评分系统构建[J]. 中国全科医学, 2021, 24(35): 4457-4462. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202135002.htm
|
| [7] |
孙璐, 张文静, 孙彬. 血清sICAM-1和sVCAM-1水平对急性心肌梗死患者行PCI术后心血管事件的影响[J]. 中国老年学杂志, 2022, 42(7): 1537-1540. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202207001.htm
|
| [8] |
谢静, 阿米娜·达伍提, 阿那古丽·阿不力米提, 等. 血清SFRP5、sMFAP4水平与急性心肌梗死伴高血压患者PCI后支架内再狭窄的关系[J]. 山东医药, 2023, 63(1): 51-55. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY202301008.htm
|
| [9] |
卢才义. 临床心血管介入操作技术[M]. 2版. 北京: 科学出版社, 2009: 115-119.
|
| [10] |
孙召金, 冯俊, 余世成, 等. 老年急性心肌梗死患者PCI治疗后6个月不良心血管事件发生的影响因素[J]. 中国老年学杂志, 2022, 42(13): 3123-3126. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202213004.htm
|
| [11] |
张骁, 宗刚军, 沈沁. 血浆微小核糖核酸-21对急性心肌梗死患者心肌缺血程度及预后的评估价值分析[J]. 实用临床医药杂志, 2021, 25(18): 97-101, 106. doi: 10.7619/jcmp.20212183
|
| [12] |
马瑞聪, 杲建波, 茆诗源, 等. 血糖间隙对急性心肌梗死患者院内主要不良心血管事件的预测价值[J]. 实用临床医药杂志, 2022, 26(3): 29-33, 43. doi: 10.7619/jcmp.20213795
|
| [13] |
匡龙, 徐芳, 吴春苑, 等. 左心室整体纵向应变对急性心肌梗死患者PCI术后MACE发生的预测价值[J]. 南京医科大学学报: 自然科学版, 2022, 42(12): 1745-1749. https://www.cnki.com.cn/Article/CJFDTOTAL-NJYK202212017.htm
|
| [14] |
ZINELLU A, MANGONI A A. A systematic review and meta-analysis of the effect of statin treatment on sVCAM-1 and sICAM-1[J]. Expert Rev Clin Pharmacol, 2022, 15(5): 601-620. doi: 10.1080/17512433.2022.2072294
|
| [15] |
TORP N, ISRAELSEN M, MADSEN B, et al. Level of MFAP4 in ascites independently predicts 1-year transplant-free survival in patients with cirrhosis[J]. JHEP Rep, 2021, 3(3): 100287. doi: 10.1016/j.jhepr.2021.100287
|
| [16] |
辛艳峰, 吴振华, 郭莉清, 等. 稳定型冠心病患者vWF、ET-1、sICAM-1水平对急性心肌梗死发病风险的联合预测价值[J]. 解放军医药杂志, 2022, 34(2): 74-78. https://www.cnki.com.cn/Article/CJFDTOTAL-HBGF202202017.htm
|
| [17] |
DORN L E, LAWRENCE W, PETROSINO J M, et al. Microfibrillar-associated protein 4 regulates stress-induced cardiac remodeling[J]. Circ Res, 2021, 128(6): 723-737. doi: 10.1161/CIRCRESAHA.120.317146
|
| [18] |
张名林, 史键山, 邓堂, 等. 血清sMFAP4水平对下肢闭塞性动脉硬化患者支架植入术后6个月再狭窄的预测价值[J]. 血管与腔内血管外科杂志, 2021, 7(7): 816-820. https://www.cnki.com.cn/Article/CJFDTOTAL-XGQW202107012.htm
|
| [19] |
LV F Q, LIU L, FENG Q, et al. Long non-coding RNA MALAT1 and its target microRNA-125b associate with disease risk, severity, and major adverse cardiovascular event of coronary heart disease[J]. J Clin Lab Anal, 2021, 35(4): e23593. doi: 10.1002/jcla.23593
|
| [20] |
CHO H J, SHIN M S, SONG Y, et al. Severe periodontal disease increases acute myocardial infarction and stroke: a 10-year retrospective follow-up study[J]. J Dent Res, 2021, 100(7): 706-713. doi: 10.1177/0022034520986097
|
| [21] |
HALLY K E, PARKER O M, BRUNTON-O'SULLIVAN M M, et al. Linking neutrophil extracellular traps and platelet activation: a composite biomarker score for predicting outcomes after acute myocardial infarction[J]. Thromb Haemost, 2021, 121(12): 1637-1649. doi: 10.1055/s-0041-1728763
|
| [22] |
曹教育, 张理想, 詹玲, 等. 基于残余炎症风险构建的列线图模型对急性心肌梗死患者介入术后院内MACE的预测价值[J]. 第三军医大学学报, 2021, 43(18): 1821-1830. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX202118019.htm
|
© 2020 《实用临床医药杂志》编辑部
Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807
Supported by:
Beijing Renhe Information Technology Co., Ltd.
苏公网安备 32100302010246号
DownLoad: