Influence of edaravone on inflammatory factor in peripheral blood in canine with renal auto-transplantation

Obj ective To explore the influence of edaravone on inflammatory factor of pe-ripheral blood in canine with renal auto-transplantation.Methods 12 weight matched healthy mon-grel dogs were randomly divided into edaravone group (ED group )and normal saline group (PS group),6 dogs in each group.ED group was treated with edaravone by 10 mg/kg intravenous in in-traoperative,postoperative 1,2,3 days,and each for edaravone 10 mg/kg.PS group was treated with the method of using the same volume of saline.The levels of TNF-α,IL-6,IL-8,IL-10 were detected by sampling venous blood before anesthesia (T0 )and after surgery (T1 ),1 days (T2 )and 3 days (T3 )after operation respectively.Results Compared with levels of inflammatory factors of peripheral blood in T0 period,there were no significant differences of concentration in each factor. With increasing of concentration of IL-6,IL-8,TNF-α,IL-10 at T1,T2,T3(P<0.05),the lev-els raised at T1 ,reached a peak at T2 ,slightly down at T3 but still higher than T0 .Levels of TNF-α,IL-6 ,IL-8 in ED group increased in T1 ,T2 ,T3 were significantly less than the PS group (P<0.05).There was no significant difference of IL-10 between two groups (P>0.05).Conclusion Inflammatory factors significantly increase in dogs with renal allograft,and it may be associated with ischemia reperfusion inj ury in renal transplantation.Edaravone can reduce the release of in-flammatory factors,which is also its mechanism of renal protection effect.