WANG Ting, BI Weihong. Effect of large dose shock therapy of calcitriol on the treatment of the patients with end-stage renal disease complicated with secondary hyperparathyroidism[J]. Journal of Clinical Medicine in Practice, 2014, (17): 29-32,43. DOI: 10.7619/jcmp.201417009
Citation: WANG Ting, BI Weihong. Effect of large dose shock therapy of calcitriol on the treatment of the patients with end-stage renal disease complicated with secondary hyperparathyroidism[J]. Journal of Clinical Medicine in Practice, 2014, (17): 29-32,43. DOI: 10.7619/jcmp.201417009

Effect of large dose shock therapy of calcitriol on the treatment of the patients with end-stage renal disease complicated with secondary hyperparathyroidism

More Information
  • Published Date: October 16, 2014
  • Obj ective To observe and analyze the curative effect of large dose shock therapy of calcitriol on the treatment of the patients with end-stage renal disease (ESRD)complicated with secondary hyperparathyroidism (SHPT).Methods 60 patients with ESRD complicated with mod-erate or severe SHPT were selected as the research obj ects and randomly divided into the observation group and the control group,30 cases in each group.The patients in the observation group were treated with large dose shock therapy of calcitriol,while the patients in the control group were treated with routine dose therapy of calcitriol.The serum levels of calcium,phosphorus,parathy-roid hormone (PTH),hemoglobin (Hb)and hematocrit (HCT)of the patients in the two groups before and after the treatment were detected.The improvements of the skin itching of the patients were evaluated.Results The serum PTH level and the serum phosphorus levels of the patients in the two groups after the treatment were significantly lower than those before the treatment (P <0 .05 ),and the serum PTH level and the serum phosphorus levels of the patients in the observation group after the treatment were significantly lower than those in the control group (P<0 .05 ).The serum calcium level of the patients in the two groups after the treatment were significantly higher than that before the treatment (P<0 .0 5 ),and the serum calcium level of the patients in the observation group after the treatment were significantly higher than that in the control group (P<0 .05 ).The clinical efficacy in improving skin itching of the patients in the two groups were 90%and 40%,the clinical efficiency of the observation group was significantly higher than that of the control group (P<0 .05 ).Meanwhile,the proportion of the patients with the curative ef-fect of“significant”in the observation group was significantly higher than that in control group (P<0 .05 ).Hb and HCT levels of the patients in the two groups after the treatment were signif-icantly higher than those before the treatment (P<0 .05 ),and Hb and HCT levels of the patients in the observation group after the treatment were significantly higher than those in the control group (P<0 .05 ).Conclusion Application of large doses shock therapy of calcitriol in the treat-ment of ESRD complicated with SHPT can rectify the imbalance calcium and phosphorus metabolism of the patients rapidly,reduced the serum PTH level of the patients significantly,and relieve significantly the symptoms of skin itching or anemia of the patients.
  • 张艳, 黄金. 终末期肾病维持性血液透析患者依从性研究现状 [J]. 齐鲁护理杂志, 2012, (12):43.doi: 10.3969/j.issn.1006-7256.2012.12.021.
    万力, 杨林. 终末期肾病患者矿物质和骨异常的诊治进展 [J]. 医学综述, 2014(4):691.
    温静. 高频超声在继发性甲状旁腺功能亢进中的应用价值 [J]. 武警后勤学院学报(医学版), 2013, (12):1089.
    袁静, 吴龙, 查艳. 贵阳市终末期肾病维持血液透析患者现况调查 [J]. 临床荟萃, 2013(2):144.doi: 10.3969/j.issn.1004-583X.2013.02.008.
    谭焕源. 慢性肾功能衰竭继发性甲状旁腺功能亢进的治疗进展 [J]. 中国老年保健医学, 2013(3):74.doi: 10.3969/j.issn.1672-4860.2013.03.035.
    赖桂兰, 郭宗琳, 欧文芳. 维持性血液透析患者继发性甲状旁腺功能亢进超声表现及相关因素分析 [J]. 西部医学, 2013, (11):1718.doi: 10.3969/j.issn.1672-3511.2013.11.044.
    肖庆璇, 秦耀荣, 胡洁萍. 维持性血液透析患者继发性甲状旁腺功能亢进相关因素分析及护理对策 [J]. 实用临床医药杂志, 2014(2):4.
    周春柳. 维持性血液透析患者继发性甲状旁腺功能亢进治疗进展 [J]. 大家健康(学术版), 2013, (15):193.
    李英. 继发性甲状旁腺功能亢进的治疗现状 [J]. 中华肾病研究电子杂志, 2013(2):70.doi: 10.3877/cma.j.issn.2095-3216.2013.02.004.
    卢建跃, 孙新增, 张霆. 慢性肾病合并甲状旁腺亢进的外科治疗 [J]. 中国中西医结合外科杂志, 2014(1):64.
    宋莹, 夏燕平. 血液透析联合血液灌流治疗慢性肾衰竭并发继发性甲状旁腺功能亢进临床观察 [J]. 现代医药卫生, 2013, (23):3533.doi: 10.3969/j.issn.1009-5519.2013.23.006.
    丁璐. 骨化三醇对不同人群骨密度改善情况的研究 [J]. 中国医药导刊, 2013(7):1231.
    张建荣. 骨化三醇注射液治疗继发性甲状旁腺功能亢进的研究进展 [J]. 中国血液净化, 2011(2):114.doi: 10.3969/j.issn.1671-4091.2011.02.016.
    刘春秋, 刘雷, 李良志. 骨化三醇对维持性血液透析患者微炎症及氧化性应激状态的影响研究 [J]. 中国全科医学, 2013(6):516.
    Zwiech R, Dryja P, Pacina D. The assessment of cy-nacalcet (Mimpara)accompanied by alfacalcidol treatment ef-ficacy in haemodialysis patients with different secondary hy-perparathyroidism severity recognized by iPTH [J]. Wiadomosci Lekarskie, 2011(4):267.
    Sprague S M, Coyne D. Control of secondary hyper-parathyroidism by vitamin D receptor agonists in chronic kid-ney disease [J]. Clin J Am Soc Nephrol, 2010(3):512.
    冯跃华. 血液透析滤过联合骨化三醇治疗透析继发甲旁亢的临床研究 [J]. 浙江实用医学, 2013(3):187.
  • Related Articles

    [1]YANG Junxia. Effect of rehabilitation nursing intervention on the improvement of quality of life in patients with cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2019, 23(12): 96-98, 102. DOI: 10.7619/jcmp.201912028
    [2]JIANG Changhao. Effect of aerobic exercise combined with impedance exercise on movement function and quality of life in patients with cerebral apoplexy[J]. Journal of Clinical Medicine in Practice, 2017, (3): 12-14. DOI: 10.7619/jcmp.201703004
    [3]CHEN Boxiang, CHEN Ling. Effect of holistic nursing intervention on sleeping and quality of life in patients with laparoscopic gallbladder-preserving cholecystolithotomy[J]. Journal of Clinical Medicine in Practice, 2016, (20): 73-76. DOI: 10.7619/jcmp.201620023
    [4]CHEN Rende. The effect of duloxetine on sleeping quality of elderly female patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (Z1): 159-160.
    [5]GAO Lini. Effect of nursing intervention on quality of sleep and quality of life in perimenopausal women with insomnia[J]. Journal of Clinical Medicine in Practice, 2015, (18): 78-80. DOI: 10.7619/jcmp.201518025
    [6]CHEN Li. Effect study of comfortable nursing in improving sleep and life quality of patients in department of digestion[J]. Journal of Clinical Medicine in Practice, 2015, (6): 39-42. DOI: 10.7619/jcmp.201506013
    [7]Mou HongQiong. Clinical effect observation of nursing intervention of sleep quality in hospitalized patients in Cardiovascular Department[J]. Journal of Clinical Medicine in Practice, 2014, (20): 12-14. DOI: 10.7619/jcmp.201420004
    [8]ZHOU Chunhua. Effect of nursing intervention on postpartum hemorrhage and sleep quality of primiparae with caesarean section[J]. Journal of Clinical Medicine in Practice, 2014, (8): 110-112. DOI: 10.7619/jcmp.201408041
    [9]MA Zaihua. Impact of continual nursing intervention on quality of life of patients with stroke[J]. Journal of Clinical Medicine in Practice, 2013, (16): 161-163. DOI: 10.7619/jcmp.201316062
    [10]LIU Guxiu. Effect of continual nursing intervention on quality of life of patients with stroke[J]. Journal of Clinical Medicine in Practice, 2013, (16): 137-139. DOI: 10.7619/jcmp.201316053
  • Cited by

    Periodical cited type(8)

    1. 李孝辉,张晓彬,刘浩,徐继鹏,姜其学,刘磊. 苄星青霉素联合多西环素在早期梅毒治疗中的应用. 医药论坛杂志. 2025(05): 535-538 .
    2. 付家富,张红萍. 苄星青霉素联合头孢曲松钠治疗梅毒患者的效果. 中国当代医药. 2024(19): 34-38 .
    3. 许纯,李锦成,杨文彬,姜艳,杨科佼,周天祺,刘甲野. 2013—2023年扬州市梅毒流行病学特征分析. 实用临床医药杂志. 2024(21): 22-27 . 本站查看
    4. 崖顺波,陆桂甫. 头孢曲松联合苄星青霉素对梅毒患者免疫功能的影响及安全性分析. 现代医学与健康研究电子杂志. 2023(07): 92-94 .
    5. 王润龙,张海璐. 苄星青霉素联合复方甘草酸苷片治疗梅毒的临床疗效观察. 医学理论与实践. 2023(15): 2592-2594 .
    6. 吴晓燕. 复方黄柏液辅助治疗早期梅毒的效果及对RPR滴度、Wnt信号通路的影响. 中国性科学. 2023(08): 132-136 .
    7. 陈筱铮. 孕产妇妊娠期梅毒治疗对新生儿预后的影响. 中国妇幼卫生杂志. 2021(05): 44-47+52 .
    8. 乔国安,张晓忠,杨晶雪. 早期梅毒患者应用头孢曲松治疗的效果研究. 黑龙江中医药. 2021(06): 476-477 .

    Other cited types(0)

Catalog

    Article views (306) PDF downloads (0) Cited by(8)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return