Changes of serum asymmetric dimethylarginine, adiponectin and Apelin levels in coronary heart disease patients with abnormal glucose metabolism

Objective To investigate the changes of asymmetric dimethylarginine (ADMA),adiponectin (APN) and Apelin levels in coronary heart disease (CHD) patients with abnormal glucose metabolism.Methods Patients with suspected coronary artery disease (CAD) were treated with parallel selective coronary angiography (CAG),and they were divided into four groups,including 28 cases in CHD group,30 cases in CHD + IGT group,32 cases in CHD + DM group,and 33 cases in NC group.Body mass index (BMI),HOMA-IR,blood pressure,blood lipid,insulin,ADMA,APN and Apelin were measured,and Gensini score was calculated.Results The values of BMI in CHD + IGT group and CHD + DM group were significantly higher than NC group (P =0.000).FPG in CHD + DM group was significantly higher than CHD group and NC group (P =0.000).PPG in CHD + IGT group and CHD + DM group were significantly higher than CHD group and NC group (P =0.000).The values of FINS,HOMA-IR in CHD + IGT group and CHD + DM group were significantly higher than the NC group (P ＜ 0.05).APN values in CHD + IGT group and CHD + DM group were significantly lower than the NC group (P ＜ 0.0 5),and ADMA 、Apelin values in CHD + IGT group and CHD + DM group were significantly higher than the CHD group and NC group (P =0.000).Gensini score in CHD + IGT group and CHD + DM group were significantly higher than the NC group (P ＜ 0.05).Multivariate regression analysis showed that ADMA,APN and Apelin values were correlated with Gensini score.Conclusion Values of ADMA,APN and Apelin maybe correlated with the degree of abnormal glucose metabolism,and these indexes are useful in evaluating and reflecting the disease severity.