WANG Haiyan, ZHU Lixin. Role of serum endotoxin, hs-CRP and PCT in the evaluation of disease condition in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2017, (7): 21-23,27. DOI: 10.7619/jcmp.201707006
Citation: WANG Haiyan, ZHU Lixin. Role of serum endotoxin, hs-CRP and PCT in the evaluation of disease condition in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2017, (7): 21-23,27. DOI: 10.7619/jcmp.201707006

Role of serum endotoxin, hs-CRP and PCT in the evaluation of disease condition in patients with acute exacerbation of chronic obstructive pulmonary disease

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  • Objective To explore the significance of serum endotoxin,allergic C-reactive protein (hs-CRP) and calcitonin original (PCT) in the evaluation of disease condition in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 50 patients with AECOPD were selected and conducted with bacterial endotoxin examination,etiology examination and APACHE Ⅱ score evaluation.According to the bacterial endotoxin levels,the patients were divided into endotoxin negative group (n =10) and the positive group (n =40).Patients with difference APACHE Ⅱ score,hs-CRP and calcitonin original (PCT) levels were compared.Results In the 50 cases,there were 40 cases with positive endotoxin expression (80.0%).Phlegm and blood bacteria culture were positive in 9 cases (18.0%),including 1 case with pseudomonas aeruginosa,2 cases with staphylococcus aureus,2 cases with acinetobacter baumannii,4 cases with eosinophilic malt narrow of bacterium.There were significant differences of APACHE Ⅱ score in patients with different levels of endotoxin (P < 0.05).In the endotoxin positive group,hs-CRP and PCT were significantly higher than the negative group (P < 0.05).In the endotoxin positive group,serum hs-CRP and PCT in severe patients were significantly higher than those of mild group (P <0.05).Pearson correlation test showed that serum hs-CRP was positively correlated with APACHE scorein patients with AECOPD (P < 0.05).Conclusion In patients with AECOPD,serum endotoxin,hs-CRPand PCT increase significantly,and these indexes can be used as the serum markers for severity of symptoms.

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