Influence of naloxone hydrochloride injection on levels of IL-6, IL-8, IL-18 and TNF-α in patients with COPD complicated with respiratory failure

Objective To explore the influence of naloxone hydrochloride injection on levels of IL-6,IL-8,IL-18 and TNF-α in patients with COPD complicated with respiratory failure.Methods A total of 60 COPD patients with respiratory failure were randomly divided into control group (n =30) and experimental group (n =30).The control group was given conventional medical treatment,while the experimental group was treated with naloxone on the basis of the control group.Results After treatment,the inflammatory factors IL-6,IL-8,IL-18,TNF-and blood gas indicators p(CO2) in the experimental group were significantly lower than the control group (P ＜ 0.05),and blood gas indicators p (O2) and pH were significantly higher than the control group (P ＜ O.05).The pulmonary function indexes FVC,FEV1 ％ and PEF in the experimental group were significantly higher than those in the control group (P ＜ 0.05).The hospital stay in the experimental group was significantly shorter than the control group (P ＜ 0.05).The total effective rate of the experimental group was significantly higher than that of the control group (P ＜ 0.05).Conclusion Naloxone hydrochloride injection is effective in the treatment of COPD patients with respiratory failure.