Preliminary study on the changes of residual lipoprotein-cholesterol after three meals in patients with coronary heart disease

XIAO Yuanyuan; HOU Mengling; HE Shenghu

doi:10.7619/jcmp.201907003

Journal of Clinical Medicine in Practice > 2019 > 23(7): 6-11. > DOI: 10.7619/jcmp.201907003

XIAO Yuanyuan, HOU Mengling, HE Shenghu. Preliminary study on the changes of residual lipoprotein-cholesterol after three meals in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2019, 23(7): 6-11. DOI: 10.7619/jcmp.201907003

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Preliminary study on the changes of residual lipoprotein-cholesterol after three meals in patients with coronary heart disease

1.
Clinical Medical School of Yangzhou University, Subei People′s Hospital in Jiangsu Province, Yangzhou, Jiangsu, 225001
2.
First People′s Hospital of Honghe Hani and Yi Minority Autonomous Prefecture in Yunnan Province, Honghe Hani and Yi Minority Autonomous Prefecture, Yunnan, 661100

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Received Date: December 09, 2018
Accepted Date: January 14, 2019
Available Online: September 09, 2020
Published Date: April 14, 2019

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Abstract

Abstract

Objective To explore the changes of residual lipoprotein-cholesterol(RLP-C)after three meals in coronary heart disease group and control group, to explore the best time point for detecting post-prandial RLP-C levels.
Methods Thirty-one patients andcontrols were recruited and divided into coronary heart disease group and control group. Vein blood samples were collected at 4 hours of fasting and three meals, and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) concentrations were measured. Serum RLP-C levels was calculated according to the equation.
Results There were no significant differences in serum fasting TC, TG, LDL-C, non-HDL-C and RLP-C levels between CHD patients and controls(P>0.05). The CHD patients had lower HDL-C concentrations than controls(P < 0. 05). Postprandial serum TG and RLP-C levels increased significantly in CHD patients after each meal(P < 0.01), and reached the peak at 4 hours after dinner. The CHD patients had higher postprandial serum RLP-C levels after lunch and dinner, and higher serum TG level after lunch than the controls(P < 0.05).
Conclusion There was no significant difference in the concentration of fasting serum RLP-C between the two groups. However, its concentration changed more significantly at 4 hours after lunch and dinner compared to that of fasting. Therefore, the RLP-C level measured at 4 hours after lunch and dinner may be more practical in clinic.

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Preliminary study on the changes of residual lipoprotein-cholesterol after three meals in patients with coronary heart disease

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