Effect of Hongyu Peizhen Granule on inflammatory indicators in sepsis patients differentiated as pathogen involving Qifen

  Objective  To investigate effect of Hongyu Peizhen Granule on inflammatory indicators such as white blood cell(WBC), neutrophil percentage (N%), hypersensitive C reaction protein (hs-CRP), erythrocyte sedimentation rate(ESR), serum procalcitonin (PCT), arterial blood lactic acid (Lac) in sepsis patients.

  Methods  Seventy acute and critical illness patients in accordance with the diagnostic criteria of sepsis were randomly divided into two groups. The patients of two groups were all given routine western medicine treatment, the experimental group was orally or nasally given Hongyu Peizhen Granule for 7 consecutive days in addition, while the control group additionally received 1/10 dose of Hongyu Peizhen Granule as placebo. The serum levels of WBC, N%, hs-CRP, ESR, PCT and Lac in arterial blood before treatment, and at 1, 3, 7 d after treatment were measured.

  Results  Compared with the control group, the levels of N%, hs-CRP, ESR, PCT, arterial blood Lac at 7 d in the experimental group decreased more significantly (P < 0.05).

  Conclusion  Hongyu Peizhen Granule can inhibit the inflammatory reaction of sepsis patients and improve their hyperlacticemia caused by tissue hypoxia and hypoperfusion thereby improving the prognosis of sepsis patients.