TANG Jie. Effect of lentinan combined with chemotherapy in patients with gastrointestinal tumors in middle and advanced stages[J]. Journal of Clinical Medicine in Practice, 2019, 23(9): 9-12. DOI: 10.7619/jcmp.201909003
Citation: TANG Jie. Effect of lentinan combined with chemotherapy in patients with gastrointestinal tumors in middle and advanced stages[J]. Journal of Clinical Medicine in Practice, 2019, 23(9): 9-12. DOI: 10.7619/jcmp.201909003

Effect of lentinan combined with chemotherapy in patients with gastrointestinal tumors in middle and advanced stages

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  • Received Date: February 12, 2019
  • Accepted Date: March 19, 2019
  • Available Online: December 21, 2020
  • Published Date: May 14, 2019
  •   Objective  To investigate the curative effect of lentinan combined with chemotherapy in the treatment of gastrointestinal tumors in middle and advanced stages.
      Methods  A total of 60 patients with gastrointestinal tumors in middle and advanced stages who were admitted to the hospital were randomly divided into observation group (n=30) and control group (n=30). All patients were treated with FOLFOX4 (oxaliplatin, calcium folinate and fluorouracil) chemotherapy, while the observation group was additionally treated with lentinan at 3 days before chemotherapy. The short-term clinical curative effect, changes in T cell subsets, NK cell activity, Karnofsky scores of quality of life, weight and adverse reactions were compared.
      Results  The clinical curative effect of the observation group was significantly better than that of the control group (P < 0.05). There was no significant difference in the immune function indexes, Karnofsky scores or weight between the two groups before treatment (P>0.05). CD3+, CD4+, CD4+/CD8+ and NK cells in the observation group were significantly increased, while CD8+ was significantly decreased after treatment (P < 0.05). CD8+ in the control group was significantly increased after treatment, while the other indicators were decreased (P < 0.05). There were statistically significant differences between groups in above indicators(P < 0.05). The Karnofsky scores, the incidence of chemotherapy adverse reactions and weight of the observation group were significantly lower than that of the control group (P < 0.05).
      Conclusion  Lentinan combined with chemotherapy for gastrointestinal tumors in middle and advanced stages can significantly improve the immune function and quality of life, reduce weight decrease, and alleviate chemotherapy-relayed adverse reactions.
  • [1]
    李剑萍, 路萍, 王冬冬, 等. 香菇多糖联合化疗治疗晚期消化道恶性肿瘤的临床疗效[J]. 中国药物经济学, 2014, 5(s1): 151-152. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYWA2014S1109.htm
    [2]
    张永红, 张瑞娟, 齐增平, 等. 香菇多糖联合化疗治疗晚期胃癌的观察[J]. 中国肿瘤外科杂志, 2014, 6(3): 197-198. doi: 10.3969/j.issn.1674-4136.2014.03.020
    [3]
    马云飞, 孙旭, 念家云, 等. 香菇多糖联合化疗治疗晚期胃癌的Meta分析[J]. 辽宁中医杂志, 2016, 8(11): 2260-2265. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201611007.htm
    [4]
    张瑜, 俞婕, 向阳, 等. 香菇多糖联合化疗治疗中晚期老年NSCLC的临床疗效及安全性研究[J]. 肿瘤药学, 2015(3): 222-225. doi: 10.3969/j.issn.2095-1264.2015.045
    [5]
    Therasse P, 鄢践, 曾益新. 实体瘤疗效评定最新指南[J]. 国外医学: 肿瘤学分册, 2000, 6(27): 375-376. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZL200006019.htm
    [6]
    徐玉侠. 香菇多糖对中晚期胃恶性肿瘤化疗增效减毒临床观察及安全性评价[J]. 中国药物经济学, 2014, 6(7): 222-223. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYWA201407135.htm
    [7]
    林百顺, 戴勇. 香菇多糖联合FOLFOX4化疗方案治疗对中晚期胃癌患者血清VEGF、IL-10和生活质量的影响[J]. 世界华人消化杂志, 2015(33): 5372-5376. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB201533025.htm
    [8]
    王小红, 余新民, 沈祝苹, 等. 香菇多糖联合化疗对晚期结肠癌患者的临床疗效[J]. 中国医药导报, 2014, 5(17): 65-69. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201417021.htm
    [9]
    万盟, 朱余兵, 邱润泽, 等. 香菇多糖对结肠癌化疗患者免疫功能及外周血中炎症因子水平的影响[J]. 中国医药导报, 2017, 14(12): 159-163. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201712039.htm
    [10]
    乔蕾. 香菇多糖辅助化疗对中晚期胃癌的临床效果[J]. 华南国防医学杂志, 2014, 3(5): 504-505. https://www.cnki.com.cn/Article/CJFDTOTAL-HNGY201405037.htm
    [11]
    李晓利, 牛敏, 张铭, 等. 香菇多糖注射液联合化疗对晚期胃癌患者免疫功能和临床疗效的影响[J]. 陕西医学杂志, 2015, 7(12): 1624-1626. doi: 10.3969/j.issn.1000-7377.2015.12.027
    [12]
    崔洪霞, 刘永利, 蒋雪超, 等. 香菇多糖联合FOLFOX4化疗方案对中晚期胃癌患者免疫功能和生活质量的影响[J]. 中国医药, 2015, 10(7): 996-1000. doi: 10.3760/cma.j.issn.1673-4777.2015.07.020
    [13]
    王纯, 卢宏达, 孔庆志. 香菇多糖增强XELOX方案治疗晚期胃癌疗效研究[J]. 中国生化药物杂志, 2014, 34(1): 95-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYW201401035.htm
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